TRANSCUTANEOUS ANALYTE SENSORS AND MONITORS, CALIBRATION THEREOF, AND ASSOCIATED METHODS
First Claim
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1. A method of compensating for drift in an analyte concentration sensor within a biological system using only a signal from an analyte concentration sensor, comprising:
- measuring values of an analyte using an indwelling analyte concentration sensor;
determining a first slow-moving average of the measured values of the analyte over a first period of time, and basing a calibration of the sensor based at least in part on the first slow-moving average;
following the first determining, determining a second slow-moving average of the measured values of the analyte over a second period of time; and
adjusting the calibration of the sensor based at least in part on the difference between the first slow moving average and the second slow moving average.
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Abstract
Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.
11 Citations
25 Claims
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1. A method of compensating for drift in an analyte concentration sensor within a biological system using only a signal from an analyte concentration sensor, comprising:
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measuring values of an analyte using an indwelling analyte concentration sensor; determining a first slow-moving average of the measured values of the analyte over a first period of time, and basing a calibration of the sensor based at least in part on the first slow-moving average; following the first determining, determining a second slow-moving average of the measured values of the analyte over a second period of time; and adjusting the calibration of the sensor based at least in part on the difference between the first slow moving average and the second slow moving average. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An analyte sensor system, comprising:
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an indwelling analyte concentration sensor configured to measure values of an analyte and to compensate for drift within a biological system using only a signal from an analyte concentration sensor; and a processor, wherein the processor is configured to; determine a first slow-moving average of the measured values of the analyte over a first period of time, and to base a calibration of the sensor at least in part on the first slow-moving average;
thereafterdetermine a second slow-moving average of the measured values of the analyte over a second period of time; and adjust the calibration of the indwelling analyte concentration sensor based at least in part on the difference between the first slow moving average and the second slow moving average. - View Dependent Claims (14, 15, 16, 17, 18)
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19. An analyte sensor system, comprising:
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an indwelling analyte concentration sensor configured to measure values of an analyte and to compensate for drift within a biological system using only a signal from an analyte concentration sensor; and a processor, wherein the processor is configured to; determine a first slow-moving average of the measured values of the analyte over a first period of time, and to base a calibration of the sensor at least in part on the first slow-moving average;
thereafterdetermine a second slow-moving average of the measured values of the analyte over a second period of time; and adjust the calibration of the indwelling analyte concentration sensor based at least in part on the difference between the first slow moving average and the second slow moving average, wherein the adjusting occurs at a time when a sensor reading is substantially stable, or within a predetermined range of readings for a threshold period of time, whereby an occurrence of unexpected jumps in readings is reduced.
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20. A method of compensating for drift in an analyte concentration sensor within a biological system using only a signal from an analyte concentration sensor, comprising:
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measuring values of an analyte using an indwelling analyte concentration sensor; determining a first slow-moving average of the measured values of the analyte over a first set of periods of time, wherein the first set includes event-based time periods, and basing a calibration of the sensor based at least in part on the first slow-moving average; following the first determining, determining a second slow-moving average of the measured values of the analyte over a second set of periods of time, wherein the second set includes event-based time periods; and adjusting the calibration of the sensor based at least in part on the difference between the first slow moving average and the second slow moving average. - View Dependent Claims (21, 22)
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23. An analyte concentration sensor system, comprising,
an indwelling analyte concentration sensor configured to measure values of an analyte and to compensate for drift within a biological system using only a signal from an analyte concentration sensor; - and
a processor, wherein the processor is configured to; determine a first slow-moving average of the measured values of the analyte over a first set of periods of time, wherein the first set includes event-based time periods, and basing a calibration of the sensor based at least in part on the first slow-moving average;
thereafterdetermine a second slow-moving average of the measured values of the analyte over a second set of periods of time, wherein the second set includes event-based time periods; and adjust the calibration of the sensor based at least in part on the difference between the first slow moving average and the second slow moving average. - View Dependent Claims (24, 25)
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Specification