Imaging compatible electrode-set for measurement of body electrical signals and methods for fabricating the same using ink-jet printing

• US 20170079543A1
• Filed: 09/18/2016
• Published: 03/23/2017
• Est. Priority Date: 09/18/2015
• Status: Abandoned Application

• Current Assignee: Neurorex Incorporated
• Original Assignee: Neurorex Incorporated
• Inventors: Sadeghian-Motahar, Seyedhesam
• Application Number:
  US15/268,600
• Publication Number:
  US 20170079543A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 2562/0215 Silver or silver chloride containing
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 2562/18 Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/276 Protection against electrode failure
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/4806 Sleep evaluation A61B5/4821 takes precedence; devices for inducing sleep A61M21/02
• CPC Class Codes: A61N 1/086 Magnetic resonance imaging [MRI] compatible leads

Abstract

This invention relates to devices and methods for measuring and/or recording electrical signals from a body, particularly to devices and methods for recording electrical signals from a body while inside a medical imaging device, such as magnetic field scanner, such as a magnetic resonance imaging (MRI) scanner, or a computerized tomography (CT) scanner, and more particularly to devices, such as headpieces with electrodes and conductive pathways, and methods for synthesis of conductive inks used to fabricate the devices, such as with inkjet printer technology. Inkjet compatible inks may be utilized that employ nanoparticle solutions or metalorganic decomposition to generate metallic depositions, such as of silver, without sintering or other secondary processing in predetermined, including customized, layouts.

Claims

1. A device for measuring electrical activity from a human or mammalian body part comprising:

a flexible substrate, said flexible substrate comprising a substantially planar non-electrically conductive material;

a plurality of electrodes disposed on said flexible substrate at a set of predetermined positions physically corresponding to a set of predetermined positions of interest on a body, said electrodes comprising a thin layer of conductive material;

an interface connector attached to said flexible substrate adapted to electrically communicate with an electrical signal measuring device;

a plurality of conductive traces disposed on said flexible substrate, each of said conductive traces electrically connecting one of said electrodes with an interface connector and comprising a thin layer of conductive material;

wherein said conductive traces are spaced on said flexible substrate at a distance from each other that prevents electrical communication between them.

2. The device of claim 1, wherein said electrodes and conductive traces are disposed on said flexible substrate by inkjet printing of an inkjet-compatible ink formulation containing a metal nanoparticle solution (NP) or a metal organic decomposition formulation (MOD).

3. The device of claim 1, wherein said flexible substrate is selected from the group consisting of a polymer film, paper, foil, foam sheet and a non-woven fiber sheet.

4. The device of claim 1, wherein said flexible substrate is formed to remove excess material from around said electrodes and said conductive traces.

5. The device of claim 3, wherein said flexible substrate comprises a polymer film selected from the group consisting of PET, BoPET, polyimide, polyethylene naphthalate, FEP, PFA, Teflon, PTFE, polyurethane, silicone, polyester, and vinyl.

6. The device of claim 1, further comprising a plurality of penetrators adapted to pierce through hair cover to contact a surface on a human or mammalian body, each of said penetrators being disposed adjacent to one of said electrodes and providing an electrically conductive connection between said electrodes and said surface of a human or mammalian body.

7. The device of claim 6, wherein said penetrators comprise a fluid reservoir prefilled with a conductive fluid or gel.

8. The device of claim 4, wherein said flexible substrate is formed to the shape of a headpiece for EEG.

9. The device of claim 2, wherein said NP solution or MOD formulation generates said electrodes and conductive traces from a metal selected from the group consisting of silver, gold, copper and aluminum.

10. The device of claim 6, wherein each of said penetrators comprise at least one adhesive surface for attaching to said flexible substrate or to said surface of a human or mammalian body.

11. A method for fabricating a set of electrodes on a substrate comprising:

providing a substrate, said substrate being sized and adapted for processing in an inkjet printer;

providing an ink formulation, said ink formulation comprising a metal nanoparticle solution (NP) or a metalorganic decomposition formulation (MOD) and being inkjet printing compatible;

applying said ink formulation to said substrate by inkjet printing in a formation that comprises a plurality of electrodes at predetermined positions and a plurality of traces connecting said electrodes to an area of said substrate designated for connecting to an electrical signal connector, said traces being spaced on said substrate to prevent electrical contact between them; and

activating said ink formulation to produce continuous and conductive metal depositions that form said electrodes and said traces;

wherein said continuous and conductive metal depositions form thin layers of metal on said substrate.

12. The method of claim 11, wherein said activating comprises heating said substrate prior to or during said applying of said ink formulation to activate.

13. The method of claim 11, further comprising forming said substrate to the shape of a headpiece for EEG.

14. The method of claim 13, wherein said forming comprises removing excess material of said substrate.

15. The method of claim 11, further comprising applying a protective layer over said traces.

16. A method for fabricating a custom set of electrodes on a substrate comprising:

determining a set of desired electrode placement locations on a subject by marking three dimensional positions and generating a first data set;

projecting said first data set from three dimensional positions to two dimensional positions;

generating a layout of electrode and trace positions using said two dimensional positions, said traces connecting said electrodes to an area of a substrate designated for connecting to an electrical signal connector and said traces being spaced on said substrate to prevent electrical contact between them;

providing said substrate, said substrate being sized appropriately to encompass said layout and adapted for processing in an inkjet printer;

providing an ink formulation, said ink formulation comprising a metal nanoparticle solution (NP) or a metalorganic decomposition formulation (MOD) and being inkjet printing compatible;

applying said ink formulation to said substrate by inkjet printing; and

activating said ink formulation to produce continuous and conductive metal depositions that form said electrodes and said traces;

wherein said continuous and conductive metal depositions form thin layers of metal on said substrate.

17. The method of claim 16, wherein said activating comprises heating said substrate prior to or during said applying of said ink formulation to activate.

18. The method of claim 16, further comprising forming said substrate to the shape of a headpiece for EEG by removing excess material of said substrate.

19. The method of claim 16, further comprising applying a protective layer over said traces.

20. The method of claim 16, wherein said determining is based on measurements of nasion to inion, left ear preaurical point to right ear preaurical point, head circumference and generation of points based on a standard 10-20 electrode placement.