ANTI-TIGIT ANTIBODIES AND METHODS OF USE
First Claim
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1. An antibody that specifically binds to human TIGIT, wherein the antibody binds to an epitope on human TIGIT comprising one or more of amino acid residues Ser78, Ser80, and Lys82 of human TIGIT.
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Abstract
The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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Citations
182 Claims
- 1. An antibody that specifically binds to human TIGIT, wherein the antibody binds to an epitope on human TIGIT comprising one or more of amino acid residues Ser78, Ser80, and Lys82 of human TIGIT.
- 9. An antibody that specifically binds to human TIGIT, wherein the antibody binds to an epitope on human TIGIT comprising one or more of amino acid residues Thr55, Ser80, and Lys82 of human TIGIT.
- 20. An antibody that specifically binds to human TIGIT, wherein the antibody comprises a paratope comprising one or more amino acid residues selected from the group consisting of heavy chain variable region amino acid residues Asn32, Tyr52, Arg52b, Phe53, Lys54, Tyr56, Asp58, Tyr99, Asp100, Leu100a, Leu100b, and Ala100c and light chain variable region amino acid residues Tyr27d, Tyr92, Ser93, Thr94, and Phe96.
- 22. An antibody that specifically binds to human TIGIT, wherein the antibody binds to an epitope on human TIGIT comprising one or more amino acid residues selected from the group consisting of Gln53, His111, and Tyr113 of human TIGIT.
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25. An antibody that specifically binds to human TIGIT, wherein the antibody comprises the following six hypervariable regions (HVRs):
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an HVR-H1 comprising the amino acid sequence of SNSAAWN (SEQ ID NO;
1);an HVR-H2 comprising the amino acid sequence of KTYYRFKWYSDYAVSVKG (SEQ ID NO;
2);an HVR-H3 comprising the amino acid sequence of ESTTYDLLAGPFDY (SEQ ID NO;
3);an HVR-L1 comprising the amino acid sequence of KSSQTVLYSSNNKKYLA (SEQ ID NO;
4);an HVR-L2 comprising the amino acid sequence of WASTRES (SEQ ID NO;
5); andan HVR-L3 comprising the amino acid sequence of QQYYSTPFT (SEQ ID NO;
6). - View Dependent Claims (26, 27, 28, 29)
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30. An antibody that specifically binds to human TIGIT, wherein the antibody comprises the following six HVRs:
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an HVR-H1 comprising the amino acid sequence of SYPMN (SEQ ID NO;
17);an HVR-H2 comprising the amino acid sequence of WINTNTGNPTYVQGFTG (SEQ ID NO;
18);an HVR-H3 comprising the amino acid sequence of TGGHTYDSYAFDV (SEQ ID NO;
19);an HVR-L1 comprising the amino acid sequence of RASQVISSSLA (SEQ ID NO;
20);an HVR-L2 comprising the amino acid sequence of AASTLQS (SEQ ID NO;
21); andan HVR-L3 comprising the amino acid sequence of QHLHGYPX1N (SEQ ID NO;
22), wherein X1 is C or S. - View Dependent Claims (31, 32, 33, 34, 35)
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36. An antibody that specifically binds to human TIGIT, wherein the antibody comprises (a) a heavy chain variable region (VH) having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 34 or 35;
(b) a light chain variable region (VL) having at least 95% sequence identity to the amino acid sequence of SEQ ID NO;
36;
or (c) a heavy chain variable region as in (a) and a light chain variable region as in (b). - View Dependent Claims (37, 38)
- 34 or 35;
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39. An antibody that specifically binds to human TIGIT, wherein the antibody comprises (a) a heavy chain variable region (VH) having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 37;
(b) a light chain variable region (VL) having at least 95% sequence identity to the amino acid sequence of SEQ ID NO;
38;
or (c) a heavy chain variable region as in (a) and a light chain variable region as in (b).
- 37;
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40. An antibody that specifically binds to human TIGIT, wherein the antibody comprises (a) a heavy chain variable region (VH) having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 39;
(b) a light chain variable region (VL) having at least 95% sequence identity to the amino acid sequence of SEQ ID NO;
40;
or (c) a heavy chain variable region as in (a) and a light chain variable region as in (b).
- 39;
- 110. The method of any one of 102-109, further comprising administering to the subject a PD-1 axis binding antagonist.
Specification