MICRORNA INDUCTION OF CARDIAC REGENERATION
First Claim
Patent Images
1. A method for promoting cellular proliferation and de-differentiation of cells into stem cells for cardiac tissue regeneration, the method comprising:
- transiently contacting said cells with a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient contact is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to compostions and methods for promoting cellular proliferation and de-differentiation of cells into stem cells to foster tissue regeneration. Specifically, the invention relates to transiently administering a microRNA (miR) or its mimic for promoting cardiomyocyte proliferation and cardiac regeneration.
-
Citations
37 Claims
-
1. A method for promoting cellular proliferation and de-differentiation of cells into stem cells for cardiac tissue regeneration, the method comprising:
- transiently contacting said cells with a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient contact is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
11. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering to said subject a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
- View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
23. A method for promoting cardiomyocyte proliferation in a subject, the method comprising:
- transiently administering to said subject a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
- View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
-
35. A method for promoting cellular proliferation and de-differentiation of cells into stem cells for cardiac tissue regeneration, the method comprising:
- transiently contacting said cells with a composition comprising a microRNA (miR) cluster or its mimic, wherein said cluster comprises one or more of miR302b, miR302c, and miR367, and wherein said transient contact is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
-
36. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering to said subject a composition comprising a microRNA (miR) cluster or its mimic, wherein said cluster comprises one or more of miR302b, miR302c, and miR367, and wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
-
37. A method for promoting cardiomyocyte proliferation in a subject, the method comprising:
- transiently administering to said subject a composition comprising a microRNA (miR) cluster or its mimic, wherein said cluster comprises one or more of miR302b, miR302c, and miR367, and wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes.
Specification