Bioadhesive Strip and Method of Using Same

• US 20170100328A1
• Filed: 12/14/2016
• Published: 04/13/2017
• Est. Priority Date: 02/04/2011
• Status: Abandoned Application

• Current Assignee: Joseph E. Kovarik, Katherine Rose Kovarik
• Original Assignee: Joseph E. Kovarik, Katherine Rose Kovarik
• Inventors: Kovarik, Joseph E., Kovarik, Katherine Rose
• Application Number:
  US15/378,425
• Publication Number:
  US 20170100328A1
• Time in Patent Office: Days
• CPC Class Codes: A61F 5/566 Intra-oral devices
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008

Abstract

A bioadhesive strip includes material that is removable or dissolvable in the oral cavity and adheres to the mucosal tissue of a person'"'"'s oral cavity, with preferred embodiments including a specially textured surface on at least the outer side of an adhesive strip that faces away from the mucosal tissue to which it is attached and that has anti-microbial characteristics, bioluminescent expressions, etc. and a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human'"'"'s mouth. Methods of using the bioadhesive strip include treating snoring, sore throat conditions, GERD, NAFLD, Alzheimer'"'"'s Disease, cachexia and migraines.

Claims

1. A buccal bioadhesive strip, comprising:

a strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 .mu.m in at least a portion of said at least one surface, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 3 hours while inside a person'"'"'s mouth, said strip including at least one polymer selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and mixtures thereof; and

wherein said strip includes between 0.2 and 0.9% xylitol by weight.

2. The strip of claim 1 wherein said strip further includes a toxic substance associated with the strip that is effective to kill undesired bacteria in the mouth.

3. The strip of claim 1 wherein said strip comprises bioluminescent material.

4. The strip of claim 1 wherein said strip comprises a non-fast drying adhesive.

5. The strip of claim 1 wherein said strip includes at least 200 mg of xylitol.

6. The strip of claim 1 wherein said strip includes phase change materials.

7. The strip of claim 1 wherein said strip further comprises an antibiotic effective to kill spirochetes bacteria.

8. The strip of claim 1 wherein said strip comprises structural features that direct airflow in a manner that further reduces the occasion of throat tissue vibration, such features selected from the group consisting of grooves, hollow structures and curved, elevated surfaces.

9. The film as set forth in claim 1, wherein said strip comprises Prevotella bacteria.

10. The film as set forth in claim 1, wherein said strip includes one of bacterial and helminth components effective to trigger an immune response in a user.

11. The strip of claim 1 wherein said strip has at least one active ingredient encapsulated inside a frangible capsule that may be broken by a person pressing against said strip with the person'"'"'s tongue.

12. The strip of claim 1 wherein said strip has compounds residing thereon to facilitate the growth of desired bacteria beneficial to a person'"'"'s health.

14. The strip of claim 1 wherein said strip is non-dissolvable in a person'"'"'s mouth.

15. The strip of claim 1 wherein said strip is dissolvable in a person'"'"'s mouth within a period of 3 hours.

13. A buccal bioadhesive strip, comprising:

a strip adapted to adhere to a mucosal membrane, said strip having at least one surface that comprises a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 .mu.m in at least a portion of said at least one surface.

16. A buccal bioadhesive strip, comprising:

a strip having at least one surface having a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature wherein an average spacing between adjacent ones of said features is between 0.5 and 5 .mu.m, said strip having a first and second side, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip extends over a majority of the soft palate, and wherein said strip includes at least one polymer selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and mixtures thereof; and

wherein said strip includes between 0.2 and 0.9% xylitol by weight.

17. The film as set forth in claim 16, wherein said strip further comprises an antibiotic effective to kill spirochetes bacteria.

18. The film as set forth in claim 16, wherein said strip includes at least about 200 mg. xylitol.

19. The film as set forth in claim 16, wherein said strip glows in the dark.

20. The film as set forth in claim 16, wherein said strip includes one of bacterial and helminth components effective to trigger an immune response in a user.