INTRA-OPERATIVE USE OF FLUORESCENCE SPECTROSCOPY AND APPLICATIONS OF SAME
First Claim
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1. A process for intra-operatively providing anatomical guidance in endocrine surgery, comprising the steps of:
- (a) illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength;
(b) obtaining Raman data from light scattered from the illuminated tissues;
(c) finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data; and
(d) identifying the thyroid or parathyroid tissues from the corresponding Raman signatures.
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Abstract
In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining Raman data from light scattered from the illuminated tissues, finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data, and identifying the thyroid or parathyroid tissues from the corresponding Raman signatures.
6 Citations
15 Claims
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1. A process for intra-operatively providing anatomical guidance in endocrine surgery, comprising the steps of:
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(a) illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength; (b) obtaining Raman data from light scattered from the illuminated tissues; (c) finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data; and (d) identifying the thyroid or parathyroid tissues from the corresponding Raman signatures. - View Dependent Claims (2, 3)
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4. A system for intra-operatively providing anatomical guidance in endocrine surgery, comprising:
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(a) a light source configured to emit light having a predetermined wavelength; (b) an optical probe optically connected to the light source and configured to deliver a beam of light to tissues in the neck area of a living subject and to collect light scattered from the tissues; (c) a detector optically coupled with the optical probe, for obtaining Raman data from the collected scattered light and rejecting signals from within the optical probe; and (d) a controller in communication with the detector and programmed for finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data and identifying tissues that correspond to the Raman signatures as thyroid or parathyroid tissues. - View Dependent Claims (5, 6, 7)
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8. A process for intra-operatively providing disease detection in endocrine surgery, comprising the steps of:
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(a) illuminating tissues in the neck area of a living subject; (b) obtaining Raman data from light scattered from the illuminated tissues; (c) finding Raman signatures corresponding to diseased thyroid or parathyroid tissues from the obtained Raman data; and (d) identifying the diseased thyroid or parathyroid tissues from the corresponding Raman signatures. - View Dependent Claims (9, 10, 11)
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12. A system for intra-operatively providing disease detection in endocrine surgery, comprising:
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(a) a light source; (b) an optical probe optically connected to the light source and configured to deliver a beam of light to tissues in the neck area of a living subject and collect light scattered from the tissues; (c) a detector optically coupled with the optical probe, for obtaining Raman data from the collected light while rejecting signals generated from within the probe itself; and (d) a computer in communication with the detector and programmed for finding Raman signatures from the obtained Raman data and identifying tissues corresponding to the Raman signatures as representing thyroid or parathyroid disease. - View Dependent Claims (13, 14, 15)
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Specification