HYDROGEL COMPOSITION AND METHOD FOR USING THE SAME

• US 20170106125A1
• Filed: 10/14/2016
• Published: 04/20/2017
• Est. Priority Date: 10/16/2015
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: WANG, Yu-Chi, CHEN, Sen-Lu, LIN, Tsai-Yu, YU, Wei-Lin, SHEN, Hsin-Hsin, CHEN, Chin-Fu, HSIEH, Meng-Yow, LIOU, Yu-Bing, LI, Pei-Shan
• Granted Patent: US 10,449,272 B2
• Time in Patent Office: Days
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

Claims

1. A hydrogel composition, comprising

a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows:

A-B-BOX-B-A, Formula (I);

B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II),

wherein, the polymer block A is a hydrophilic polyethylene glycol polymer, the polymer block B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′

-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and

an anti-adhesion additive,

wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

2. The hydrogel composition as claimed in claim 1, wherein the polymer block A comprises polyethylene glycol (PEG) or methoxy-poly(ethylene glycol) (mPEG).

3. The hydrogel composition as claimed in claim 1, wherein the polymer block B comprises poly(lactide-co-glycolide) (PLGA), poly(propionic-co-lactic (PPLA), poly(valeric-co -lactic) (PVLA) or poly(caproic-co-lactic) (PCLA).

4. The hydrogel composition as claimed in claim 1, wherein a weight percentage of the anti-adhesion additive is 0.2-75 wt %, based on the total weight of the hydrogel composition.

5. The hydrogel composition as claimed in claim 1, wherein the carbohydrate comprises glucose, hyaluronic acid, carboxymethyl cellulose or a combination thereof.

6. The hydrogel composition as claimed in claim 1, wherein the nitrogen-containing cyclic compound comprises polyvinylpyrrolidone (PVP), vancomycin or a combination thereof.

7. The hydrogel composition as claimed in claim 1, wherein the polymer is a hydrophilic polymer comprising poly(acrylic) acid (PAA), poly(vinyl alcohol) (PVA), poly(ethylene glycol)diacrylate (PEGDA) or a combination thereof.

8. The hydrogel composition as claimed in claim 1, wherein the polymer is a hydrophilic polymer comprising collagen, gelatin or a combination thereof.

9. The hydrogel composition as claimed in claim 1, wherein the hydrogel composition is powder.

10. The hydrogel composition as claimed in claim 9, wherein a particle size of the powder is between 0.1 μ

m and 1 mm.

11. The hydrogel composition as claimed in claim 1, wherein the hydrogel composition is dissolved in water to become a liquid at a first temperature.

12. The hydrogel composition as claimed in claim 11, wherein a viscosity of the liquid is less than 100 Pa-s.

13. The hydrogel composition as claimed in claim 11, wherein the liquid becomes a gel at a second temperature.

14. The hydrogel composition as claimed in claim 13, wherein a viscosity range of the gel is between 200 Pa-s and 250 Pa-s.

15. A method for using a hydrogel composition, comprising:

dissolving the hydrogel composition as claimed in claim 1 in water at a first temperature to form a liquid; and

applying the liquid to a substrate, wherein the substrate has a second temperature, and the liquid forms into a gel at the second temperature.

16. The method for using a hydrogel composition as claimed in claim 15, wherein the first temperature is between 4°

C. and 30°

C.

17. The method for using a hydrogel composition as claimed in claim 15, wherein a viscosity of the liquid is less than 100 Pa-s.

18. The method for using a hydrogel composition as claimed in claim 15, wherein the second temperature is between 30°

C. and 55°

C.

19. The method for using a hydrogel composition as claimed in claim 15, wherein a viscosity range of the gel is between 200 Pa-s and 250 Pa-s.