CYCLOPROPYLAMINES AS LSD1 INHIBITORS
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Abstract
The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
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Citations
88 Claims
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1-51. -51. (canceled)
- 52. A method of treating a disease, wherein said disease is selected from sickle cell disease, leiomyosarcoma, hepatocellular carcinoma, small cell lung cancer, Ewing'"'"'s sarcoma, neuroblastoma, glioblastoma, breast cancer, prostate cancer, and ovarian cancer, comprising administering to a patient a therapeutically effective amount of a compound of Formula IIIa:
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53. A method of treating a disease, wherein said disease is selected from sickle cell disease, leiomyosarcoma, hepatocellular carcinoma, small cell lung cancer, Ewing'"'"'s sarcoma, neuroblastoma, glioblastoma, breast cancer, prostate cancer, and ovarian cancer, comprising administering to a patient a therapeutically effective amount of a compound of Formula IIIa:
Specification