BISPECIFIC ANTIBODIES SPECIFIC FOR PD1 AND TIM3
First Claim
1. A bispecific antibody comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, whereinsaid first antigen-binding site specifically binding to PD1 comprisesa VH domain comprising(i) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 37,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
38, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
39; and
a VL domain comprising(i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
40;
(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
41, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
42; and
said second antigen-binding site specifically binding to TIM3 comprises(a) a VH domain comprising(i) HVR-H1 comprising the amino acid sequence of SEQ ID NO;
1,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
2, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
3; and
a VL domain comprising(i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
4 or SEQ ID NO;
11 or SEQ ID NO;
12,(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
5, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
6;
or(b) a VH domain comprising(i) HVR-H1 comprising the amino acid sequence of SEQ ID NO;
17,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
18, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
19; and
a VL domain comprising(i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
20,(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
21, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
22;
or(c) a VH domain comprising(i) HVR-H1 comprising the amino acid sequence of SEQ ID NO;
29,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
30, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
31; and
a VL domain comprising(i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
32,(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
33, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
34.
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Accused Products
Abstract
The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
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Citations
30 Claims
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1. A bispecific antibody comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, wherein
said first antigen-binding site specifically binding to PD1 comprises a VH domain comprising (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO: - 37,
(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
38, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
39; anda VL domain comprising (i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
40;(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
41, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
42; andsaid second antigen-binding site specifically binding to TIM3 comprises (a) a VH domain comprising (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO;
1,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
2, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
3; anda VL domain comprising (i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
4 or SEQ ID NO;
11 or SEQ ID NO;
12,(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
5, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
6;
or(b) a VH domain comprising (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO;
17,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
18, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
19; anda VL domain comprising (i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
20,(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
21, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
22;
or(c) a VH domain comprising (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO;
29,(ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
30, and(iii) HVR-H3 comprising an amino acid sequence of SEQ ID NO;
31; anda VL domain comprising (i) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
32,(ii) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
33, and(iii) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
34. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 30)
- 37,
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25. (canceled)
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26. (canceled)
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27. (canceled)
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28. (canceled)
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29. (canceled)
Specification