IONTOPHORETIC DRUG DELIVERY METHOD
First Claim
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1. A method of administering a therapeutic agent to a patient with an iontophoretic drug delivery system, the method comprising the steps of:
- (a) removing a drug pack component of the iontophoretic drug delivery system and an iontophoresis patch component of the iontophoretic drug delivery system from a storage package and removing one or more of the cover membranes and release liners;
(b) assembling the iontophoretic drug delivery system by combining the drug pack component and the iontophoresis patch component, the assembling step including aligning the drug pack component and the iontophoresis patch component relative to one another with an alignment structure and affixing the drug pack component and the iontophoresis patch component into permanent adhesive contact forming a transdermal iontophoresis patch that is ready to use, wherein said alignment structure is either;
(1) a folding support structure associated with the drug pack component and the iontophoresis patch component, the folding support structure including a separator component configured to physically separate and protect the drug pack component and the iontophoresis patch component when the iontophoretic drug delivery system is present in a folded storage state;
or(2) a separate guide element including a raised alignment members configured to register with the drug pack component and the iontophoresis patch component for separate consecutive alignment of the drug pack component with the iontophoresis patch component; and
(c) applying the transdermal iontophoresis patch to the skin of the patient at a desired location.
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Abstract
The present invention relates generally to iontophoretic drug delivery systems for transdermal delivery of therapeutic agents and, more particularly, to packaging such systems for long shelf life and easy assembly for use. The system package includes an iontophoretic skin worn patch component that accommodates a power source, electronics, electrodes and a drug pack component that carries a therapeutic agent which is contained as a separate sealed component. The packaged system further provides for ease of assembly at the time of use.
3 Citations
27 Claims
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1. A method of administering a therapeutic agent to a patient with an iontophoretic drug delivery system, the method comprising the steps of:
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(a) removing a drug pack component of the iontophoretic drug delivery system and an iontophoresis patch component of the iontophoretic drug delivery system from a storage package and removing one or more of the cover membranes and release liners; (b) assembling the iontophoretic drug delivery system by combining the drug pack component and the iontophoresis patch component, the assembling step including aligning the drug pack component and the iontophoresis patch component relative to one another with an alignment structure and affixing the drug pack component and the iontophoresis patch component into permanent adhesive contact forming a transdermal iontophoresis patch that is ready to use, wherein said alignment structure is either; (1) a folding support structure associated with the drug pack component and the iontophoresis patch component, the folding support structure including a separator component configured to physically separate and protect the drug pack component and the iontophoresis patch component when the iontophoretic drug delivery system is present in a folded storage state;
or(2) a separate guide element including a raised alignment members configured to register with the drug pack component and the iontophoresis patch component for separate consecutive alignment of the drug pack component with the iontophoresis patch component; and (c) applying the transdermal iontophoresis patch to the skin of the patient at a desired location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of administering a therapeutic agent to a patient with an iontophoretic drug delivery system, the method comprising the steps of:
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removing a separator component from a drug pack component having a gel pad, the separator component configured to be interposed between and thereby physically separate and protect the drug pack component and an iontophoresis patch component when the iontophoretic drug delivery system is present in a fully folded storage stage; folding a folding support structure to align an iontophoresis patch component with the drug pack component, wherein said iontophoresis patch component is configured to align said gel pads of said drug pack component in conductive relation in an assembled state, the folding support structure is associated with the drug pack component and the iontophoresis patch component; and applying the iontophoretic drug delivery system in the assembled state to the skin of the patient. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification