ANTI-IL1RAP ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND IL1RAP AND CD3, AND USES THEREOF
First Claim
1. An isolated antibody, or an antigen-binding fragment thereof, that binds specifically to IL1RAP comprising:
- an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
68 and a light chain sequence set forth in SEQ ID NO;
69;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
70 and a light chain sequence set forth in SEQ ID NO;
71;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
72 and a light chain sequence set forth in SEQ ID NO;
73;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
74 and a light chain sequence set forth in SEQ ID NO;
75;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
76 and a light chain sequence set forth in SEQ ID NO;
77;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
78 and a light chain sequence set forth in SEQ ID NO;
79;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
80 and a light chain sequence set forth in SEQ ID NO;
79;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
81 and a light chain sequence set forth in SEQ ID NO;
82;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
83 and a light chain sequence set forth in SEQ ID NO;
84;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
85 and a light chain sequence set forth in SEQ ID NO;
84;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
86 and a light chain sequence set forth in SEQ ID NO;
84;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
74 and a light chain sequence set forth in SEQ ID NO;
87;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
76 and a light chain sequence set forth in SEQ ID NO;
88;
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
76 and a light chain sequence set forth in SEQ ID NO;
89;
oran antibody comprising a heavy chain sequence set forth in SEQ ID NO;
90 and a light chain sequence set forth in SEQ ID NO;
91.
8 Assignments
0 Petitions
Accused Products
Abstract
Provided herein are antibodies that specifically bind to IL1RAP. Also described are related polynucleotides capable of encoding the provided IL1RAP-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor IL1RAP-expressing cancer progression, regression, or stability; to determine whether or not a patient should be treated for cancer; or to determine whether or not a subject is afflicted with IL1RAP-expressing cancer and thus may be amenable to treatment with an IL1RAP-specific anti-cancer therapeutic, such as the multispecific antibodies against IL1RAP and CD3 described herein.
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Citations
30 Claims
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1. An isolated antibody, or an antigen-binding fragment thereof, that binds specifically to IL1RAP comprising:
-
an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
68 and a light chain sequence set forth in SEQ ID NO;
69;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
70 and a light chain sequence set forth in SEQ ID NO;
71;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
72 and a light chain sequence set forth in SEQ ID NO;
73;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
74 and a light chain sequence set forth in SEQ ID NO;
75;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
76 and a light chain sequence set forth in SEQ ID NO;
77;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
78 and a light chain sequence set forth in SEQ ID NO;
79;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
80 and a light chain sequence set forth in SEQ ID NO;
79;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
81 and a light chain sequence set forth in SEQ ID NO;
82;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
83 and a light chain sequence set forth in SEQ ID NO;
84;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
85 and a light chain sequence set forth in SEQ ID NO;
84;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
86 and a light chain sequence set forth in SEQ ID NO;
84;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
74 and a light chain sequence set forth in SEQ ID NO;
87;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
76 and a light chain sequence set forth in SEQ ID NO;
88;an antibody comprising a heavy chain sequence set forth in SEQ ID NO;
76 and a light chain sequence set forth in SEQ ID NO;
89;
oran antibody comprising a heavy chain sequence set forth in SEQ ID NO;
90 and a light chain sequence set forth in SEQ ID NO;
91. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An isolated IL1RAP×
- CD3 bispecific antibody comprising;
a) a first heavy chain (HC1); b) a second heavy chain (HC2); c) a first light chain (LC1); and d) a second light chain (LC2), wherein the HC1 and the LC1 pair to form a first antigen-binding site that specifically binds CD3, and the HC2 and the LC2 pair to form a second antigen-binding site that specifically binds IL1RAP, or an IL1RAP×
CD3 bispecific binding fragment thereof.- View Dependent Claims (9, 10, 11, 12, 13)
- CD3 bispecific antibody comprising;
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14. An isolated IL1RAP×
- CD3 bispecific antibody or an IL1RAP×
CD3 bispecific binding fragment thereof comprising;a) a first heavy chain (HC1); b) a second heavy chain (HC2); c) a first light chain (LC1); and d) a second light chain (LC2), wherein the HC1 and the LC1 pair to form a first antigen-binding site that specifically binds CD3 and comprise a heavy chain CDR1 (HCDR1) as depicted in SEQ ID NO;
96, an HCDR2 as depicted in SEQ ID NO;
102, an HCDR3 as depicted in SEQ ID NO;
98 a light chain CDR1 (LCDR1) as depicted in SEQ ID NO;
99, an LCDR2 as depicted in SEQ ID NO;
100, and an LCDR3 as depicted in SEQ ID NO;
101;and the HC2 and the LC2 pair to form a second antigen-binding site that specifically binds IL1RAP and comprise a heavy chain CDR1 (HCDR1) as depicted in SEQ ID NO;
16 or 22, an HCDR2 as depicted in SEQ ID NO;
17 or 23, an HCDR3 as depicted in SEQ ID NO;
18 or 24 a light chain CDR1 (LCDR1) as depicted in SEQ ID NO;
46 or 62, an LCDR2 as depicted in SEQ ID NO;
47 or 63, and an LCDR3 as depicted in SEQ ID NO;
103 or 64.- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- CD3 bispecific antibody or an IL1RAP×
Specification