LINKAGE MODIFIED GAPPED OLIGOMERIC COMPOUNDS AND USES THEREOF
First Claim
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21-1. The gapped oligomeric compound of claim 1 further comprising at least one 5′
- or 3′
-conjugate group.
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Abstract
The present invention provides gapped oligomeric compounds. More particularly the gapped oligomeric compounds provided herein comprise at least one modified internucleoside linkage in the gap region. Such gapped oligomeric compounds have one or more improved properties such as selectivity, potency, improved toxicity profile and or improved proinflammatory profile. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
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23 Claims
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21-1. The gapped oligomeric compound of claim 1 further comprising at least one 5′
- or 3′
-conjugate group.
- or 3′
Specification