TOPICAL COMPOSITIONS AND METHODS FOR SKIN LIGHTENING

• US 20170135926A1
• Filed: 01/31/2017
• Published: 05/18/2017
• Est. Priority Date: 09/30/2014
• Status: Abandoned Application

• Current Assignee: Avon Products Incorporated
• Original Assignee: Avon Products Incorporated
• Inventors: Santhanam, Uma, Lyga, John W., Yim, Sunghan, Hu, Hong
• Application Number:
  US15/420,257
• Publication Number:
  US 20170135926A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 2800/42 Colour properties
• CPC Class Codes: A61K 2800/48 Thickener, Thickening system
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/064 Water-in-oil emulsions, e.g. Water-in-silicone emulsions
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/46 containing sulfur A61K8/44 takes precedence
• CPC Class Codes: A61K 8/49 containing heterocyclic compounds
• CPC Class Codes: A61K 8/4926 having six membered rings
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin

Abstract

Embodiments of the invention are generally directed to compositions useful for reducing pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3′-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a topically acceptable vehicle.

Claims

1. A topical composition comprising, in a topically acceptable vehicle, an effective amount of a compound having the structure of formula (I):

2. The composition according to claim 1, wherein said topically acceptable vehicle comprises a water-in-oil, oil-in-water, silicone-in-water, or water-in-silicone emulsion and further comprises an emulsifier.

3. The composition according to claim 1, wherein said effective amount is from about 0.0001% to about 5% by weight based on the total weight of the composition.

4. The composition according to claim 1, further comprising a retinoid in an amount from about 0.001% to about 5% by weight based on the total weight of the composition.

5. The composition according to claim 1, further comprising at least one other ingredient selected from a film forming polymer, a thickener, a pH adjuster, a preservative, an emulsifier, a gelling agent, an antioxidant, an emollient, a humectant, a fragrance, and a colorant.

6. The composition according to claim 1, further comprising at least one other depigmenting agent selected from nicotinamide, 3,3′

-thiodipropanoic acid, dilauryl thiodipropionate, Kojic acid, hydroquinone, salicylic acid, and resorcinol.

7. A topical composition comprising, in a topically acceptable vehicle, an effective amount of a compound having the structure of formula (II):

8. The composition according to claim 7, wherein said topically acceptable vehicle comprises a water-in-oil, oil-in-water, silicone-in-water, or water-in-silicone emulsion and further comprises an emulsifier.

9. The composition according to claim 7, wherein said effective amount is from about 0.0001% to about 5% by weight based on the total weight of the composition.

10. The composition according to claim 7, further comprising a retinoid in an amount from about 0.001% to about 5% by weight based on the total weight of the composition.

11. The composition according to claim 7, further comprising at least one other ingredient selected from a film forming polymer, a thickener, a pH adjuster, a preservative, an emulsifier, a gelling agent, an antioxidant, an emollient, a humectant, a fragrance, and a colorant.

12. The composition according to claim 7, further comprising at least one other depigmenting agent selected from nicotinamide, 3,3′

-thiodipropanoic acid, dilauryl thiodipropionate, Kojic acid, hydroquinone, salicylic acid, and resorcinol.

13-18. -18. (canceled)