×

METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF IMMUNE CELLS

  • US 20170137783A1
  • Filed: 07/21/2016
  • Published: 05/18/2017
  • Est. Priority Date: 07/21/2015
  • Status: Active Grant
First Claim
Patent Images

1. A method of expanding and/or activating a population of immune cells, comprising:

  • introducing a nucleic acid encoding a first Chimeric Antigen Receptor (CAR) molecule into the immune cell population, under conditions suitable for transient expression of the CAR molecule, thereby producing a first CAR-expressing cell population, wherein the CAR molecule comprises an antigen binding domain of an antibody molecule; and

    contacting the first CAR-expressing cell population with a ligand of the CAR antigen binding domain chosen from a cognate antigen molecule, or an anti-antigen idiotypic antibody molecule, under conditions such that immune cell expansion and/or activation occurs, thereby producing an expanded and/or activated immune cell population.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×