COMPOSITIONS AND METHODS FOR DISINFECTING AND CLEANING CONTACT LENSES

• US 20170142964A1
• Filed: 02/01/2017
• Published: 05/25/2017
• Est. Priority Date: 09/27/2013
• Status: Abandoned Application

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Ketelson, Howard Allen, Muya, Leroy Wainaina
• Application Number:
  US15/421,835
• Publication Number:
  US 20170142964A1
• Time in Patent Office: Days
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A61L 12/128 neutralised with catalysts
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

This invention relates generally to disinfection and cleaning systems for medical devices. In a preferred embodiment, the invention relates to compositions, methods and articles for simultaneously cleaning and disinfecting contact lenses. The present invention is directed to ophthalmic compositions containing one or more block copolymers referred to as (polyoxyethylene)-(poly-oxybutylene) block copolymers (“PEO-PBO”). The invention is particularly directed to the use of PEO-PBO di-block copolymers as non-foaming wetting agents in peroxide-based compositions for disinfecting contact lenses.

Claims

1-18. -18. (canceled)

19. A composition for disinfecting a contact lens, comprising about 0.5 w/v % to about 6 w/v % by weight hydrogen peroxide, at least one poly(oxyethylene)-poly(oxybutylene) di-block copolymer and an effective amount of a poly (oxyethylene)-poly (oxypropylene) block copolymer having the structure:

20. A composition according to claim 19, wherein m is no less than n.

21. A composition according to claim 20, wherein the ratio of m to n is in the range of about 1:

1 to about 3;

1.

22. A composition according to claim 21, wherein the ratio of m to n is in the range of about 1.5:

1 to about 2;

1.

23. A composition according to claim 19, wherein the poly(oxyethylene)-poly(oxybutylene) di-block copolymer has a molecular weight in the range of 400 to 1,200 Daltons.

24. A composition according to claim 23, wherein the poly(oxyethylene)-poly(oxybutylene) di-block copolymer has a molecular weight in the range of 700 to 900 Daltons.

25. A composition according to claim 19, wherein the poly (oxyethylene)-poly (oxybutylene) di-block copolymer is of the formula:

26. A composition according to claim 25, wherein R is methyl;

m has an average value of 10; and

n has an average value of 5.

27. A composition according to claim 19, wherein the polyoxyethylene component of the block copolymer in poly (oxyethylene)-poly (oxypropylene) block copolymer constitutes about 40 weight percent of the block copolymer.

28. A composition according to claim 19, wherein the molecular weight of the polyoxypropylene in block poly (oxyethylene)-poly (oxypropylene) block copolymer is from about 1200 and about 3100.

29. A composition according to claim 19, wherein the molecular weight of the polyoxypropylene block in poly (oxyethylene)-poly (oxypropylene) block copolymer is about 1700.

30. A composition according to claim 19, wherein the poly (oxyethylene)-poly (oxypropylene) block copolymer is present in the range of about 0.005% to about 0.8%.

31. A composition according to claim 19, wherein said poly (oxyethylene)-poly (oxypropylene) block copolymer is present less than 0.1%.

32. A method of disinfecting a contact lens comprising the steps of:

(a) contacting a contact lens with an aqueous solution of about 0.5 w/v % to about 6 w/v % by weight hydrogen peroxide, at least one poly(oxyethylene)-poly(oxybutylene) di-block copolymer, and an effective amount of a poly (oxyethylene)-poly (oxypropylene) block copolymer having the structure;

33. A method of disinfecting a contact lens as claimed in claim 32, wherein the step of neutralizing comprises contacting said solution with a metal catalyst.

34. A method of disinfecting a contact lens as claimed in claim 32, wherein the lens is ready for insertion into the eye without a step of manually rubbing the lens.