COMBINATION OF ONCOLYTIC VIRUS WITH IMMUNE CHECKPOINT MODULATORS
First Claim
1. A method for treating a cancer, comprising administering an oncolytic poxvirus and one or more immune checkpoint modulator(s) antagonizing at least partially the activity of inhibitory immune checkpoint(s), wherein said oncolytic poxvirus and said one or more immune checkpoint modulator(s) are administered sequentially and wherein said oncolytic poxvirus is administered first and said immune checkpoint modulator(s) is administered second.
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Abstract
The present invention provides a combination comprising at least an oncolytic virus and one or more immune checkpoint modulator(s) for use for the treatment of a proliferative disease such as cancer. It also relates to a kit comprising said oncolytic virus and said one or more immune checkpoint modulator(s) in separate containers. It also concerns a pharmaceutical composition comprising effective amount of said oncolytic virus and said one or more immune checkpoint modulator(s).
30 Citations
20 Claims
- 1. A method for treating a cancer, comprising administering an oncolytic poxvirus and one or more immune checkpoint modulator(s) antagonizing at least partially the activity of inhibitory immune checkpoint(s), wherein said oncolytic poxvirus and said one or more immune checkpoint modulator(s) are administered sequentially and wherein said oncolytic poxvirus is administered first and said immune checkpoint modulator(s) is administered second.
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19. A kit comprising at least an oncolytic poxvirus in one container and one or more immune checkpoint modulator(s) antagonizing at least partially the activity of inhibitory immune checkpoint(s) in another container.
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20. A pharmaceutical composition comprising effective amounts of an oncolytic poxvirus and of one or more immune checkpoint modulator antagonizing at least partially the activity of inhibitory immune checkpoint(s).
Specification