Occlusion Device

• US 20170156734A1
• Filed: 12/07/2016
• Published: 06/08/2017
• Est. Priority Date: 12/07/2015
• Status: Active Grant

• Current Assignee: Stryker Ireland Technology Ltd. (Stryker Corporation)
• Original Assignee: Cerus Endovascular Limited (Stryker Corporation)
• Inventors: Griffin, Stephen
• Granted Patent: US 10,285,711 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12163 having a string of elements connected to each other
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00632 Occluding a cavity, i.e. closing a blind opening
• CPC Class Codes: A61B 2017/00862 elastic or resilient
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image

Abstract

Provided herein is an occlusion device for implantation into a body lumen or aneurysm comprising, a continuous compressible mesh structure comprising axial mesh carriages configured end to end, wherein each end of each carriage is a pinch point in the continuous mesh structure. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device are also disclosed.

Claims

1. An occlusion device for implantation into a body lumen or aneurysm comprising, a continuous compressible mesh structure comprising axial mesh carriages configured end to end, wherein each end of each carriage is a pinch point in the continuous mesh structure.

2. The occlusion device of claim 1, wherein a marker encircles at least one pinch point.

3. The occlusion device of claim 2, wherein the marker is radiopaque.

4. The occlusion device of claim 1, wherein the number of axial carriages is equal to (n) and (n) is selected from the group consisting of two axial carriages, three axial carriages, four axial carriages, and five axial carriages.

5. The occlusion device of claim 1, wherein at least one axial carriage comprises an inner coaxial mesh carriage or inner coaxial mesh carriages.

6. The occlusion device of claim 5, wherein the inner coaxial mesh carriages are two inner coaxial mesh carriages, or three inner coaxial mesh carriages.

7. The occlusion device of claim 5, wherein the inner coaxial mesh carriage or the inner coaxial mesh carriages is dissimilar material to its outer axial carriage.

8. The occlusion device of claim 5, wherein the inner coaxial mesh carriage or the inner coaxial mesh carriages is dissimilar mesh density to its outer axial carriage.

9. The occlusion device of claim 1, the continuous mesh structure expands in a deployed shape and fills the body lumen or aneurysm, whereby the deployed shape compresses its axial length (x) of each carriage to about 5% to about 50% of its axial length in free air.

10. The occlusion device of claim 1, wherein the axial carriages are different sizes.

11. The occlusion device of claim 1, comprising two axial carriages, wherein the two axial carriages comprise a distal axial carriage and a proximal axial carriage, and wherein the distal axial carriage has a larger diameter than the proximal axial carriage.

12. A kit for treatment and/or amelioration of a body lumen or an aneurysm;

the kit comprising;

a. an occlusion device for implantation into a body lumen or aneurysm comprising, a continuous compressible mesh structure comprising axial mesh carriages configured end to end, wherein each end of each carriage is a pinch point in the continuous mesh structure; and

b. a delivery system or detachment system corresponding to the occlusion device.

13. The kit of claim 12, wherein the delivery system is a microcatheter, catheter, guide wire, or pusher wire.

14. The kit of claim 12, wherein the detachment system is an electrolytic detachment system.

15. A method for treating or ameliorating a body lumen or an aneurysm in a patient, the method comprising:

a. delivering to a body lumen or an aneurysm an occlusion device comprising, a continuous compressible mesh structure comprising axial mesh carriages configured end to end, wherein each end of each carriage is a pinch point; and

b. deploying the occlusion device in the aneurysm, thereby treating or ameliorating the aneurysm in the patient.

16. An occlusion device for implantation into a body lumen or aneurysm comprising, a compressible continuous mesh structure comprising an axial mesh carriage, wherein each end of the carriage is a pinch point in the continuous mesh structure, and wherein the carriage comprises inner coaxial mesh carriages.

17. The occlusion device of claim 16, wherein a marker encircles at least one pinch point.

18. The occlusion device of claim 17, wherein the marker is radiopaque.

19. The occlusion device of claim 16, wherein the inner coaxial mesh carriages is dissimilar material to its outer axial carriage.

20. The occlusion device of claim 16, wherein the inner coaxial mesh carriage is dissimilar mesh density to its outer axial carriage.