ARIPIPRAZOLE FORMULATIONS HAVING INCREASED INJECTION SPEEDS
First Claim
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1. A method of treating depression or bipolar disorder in a subject in need thereof, comprising intramuscularly administering to said subject a therapeutically effective amount of a pharmaceutical composition at a continuous injection rate of 0.3 mL/s to 1 mL/s, wherein said pharmaceutical composition comprises:
- (a) 24-30 weight percent of a compound of Formula (I);
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Abstract
The present invention relates to pharmaceutical compositions comprising a compound of Formula (I) that are useful for the intramuscular delivery of antipsychotic drugs using rapid injection rates.
3 Citations
35 Claims
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1. A method of treating depression or bipolar disorder in a subject in need thereof, comprising intramuscularly administering to said subject a therapeutically effective amount of a pharmaceutical composition at a continuous injection rate of 0.3 mL/s to 1 mL/s, wherein said pharmaceutical composition comprises:
(a) 24-30 weight percent of a compound of Formula (I); - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 29)
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3. (canceled)
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16. (canceled)
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17. (canceled)
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18. (canceled)
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19. A kit for the treatment of depression or bipolar disorder, wherein the kit comprises a therapeutically effective amount of a pharmaceutical composition and further comprises instructions for intramuscular injection, wherein the instructions specify a continuous intramuscular injection within 10 seconds, wherein said pharmaceutical composition comprises:
(a) 24-30 weight percent Compound 1; - View Dependent Claims (22, 30, 31)
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20. (canceled)
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21. (canceled)
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23. A method of treating depression or bipolar disorder in a subject in need thereof, comprising intramuscularly injecting into said subject a therapeutically effective amount of a pharmaceutical composition, wherein said pharmaceutical composition comprises:
(a) 24-30 weight percent of a compound of Formula (I); - View Dependent Claims (24)
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25. A method of treating depression or bipolar disorder in a subject in need thereof, comprising intramuscularly injecting into said subject a therapeutically effective amount of a pharmaceutical composition, wherein said pharmaceutical composition comprises:
(a) 24-30 weight percent of a compound of Formula (I); - View Dependent Claims (26)
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27. A method of treating depression or bipolar disorder in a subject in need thereof, comprising intramuscularly injecting into said subject a therapeutically effective amount of a pharmaceutical composition, wherein said pharmaceutical composition comprises:
(a) 24-30 weight percent of a compound of Formula (I); - View Dependent Claims (28)
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32. A kit for the treatment of depression or bipolar disorder, wherein the kit comprises a therapeutically effective amount of a pharmaceutical composition and further comprises instructions for intramuscular injection, wherein the instructions specify a continuous intramuscular injection within 10 seconds, wherein said pharmaceutical composition comprises:
(a) 24-30 weight percent Compound 1; - View Dependent Claims (33, 34, 35)
Specification