TREATMENT OF RETINAL DEGENERATION USING PROGENITOR CELLS
First Claim
1. A method for reducing the loss of photoreceptor cells in retinal degeneration, the method comprising administering to the eye of a subject a composition comprising a population of postpartum-derived cells in an amount effective to reduce the loss of photoreceptor cells, wherein the postpartum-derived cells are isolated from human umbilical cord tissue substantially free of blood, and wherein the population of postpartum-derived cells modulates phagocytic receptors α
- vβ
5 integrin and CD36.
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Accused Products
Abstract
Methods and compositions for treating and reducing retinal degeneration using progenitor cells and conditioned media from progenitor cells, such as postpartum-derived cells are disclosed. Genetic factors and receptors expressed by the progenitor cells that aid in protection of retinal cells and inhibition of apoptosis of retinal cells such as photoreceptor cells are also disclosed.
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Citations
20 Claims
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1. A method for reducing the loss of photoreceptor cells in retinal degeneration, the method comprising administering to the eye of a subject a composition comprising a population of postpartum-derived cells in an amount effective to reduce the loss of photoreceptor cells, wherein the postpartum-derived cells are isolated from human umbilical cord tissue substantially free of blood, and wherein the population of postpartum-derived cells modulates phagocytic receptors α
- vβ
5 integrin and CD36. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- vβ
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10. A method of treating ocular degeneration in a subject comprising administering to an eye of the subject a composition comprising a population of postpartum-derived cells in an amount effective to treat the ocular degeneration, wherein the postpartum-derived cells are isolated from human umbilical cord tissue substantially free of blood, and wherein the population of postpartum-derived cells modulates phagocytic receptors α
- vβ
5 integrin and CD36. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
- vβ
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19. A method of clearing apoptotic retinal cells by phagocytes in the eye comprising administering a population of postpartum-derived cells to the eye of a subject, wherein the postpartum-derived cells are isolated from human umbilical cord tissue substantially free of blood, and wherein the population of postpartum-derived cells modulates phagocytic receptors α
- vβ
5 integrin and CD36. - View Dependent Claims (20)
- vβ
Specification