METHODS, DEVICES AND SYSTEMS FOR PULMONARY DELIVERY OF ACTIVE AGENTS
First Claim
1. A method of pulmonary delivering to a subject at least one pharmacologically active agent, the method comprising:
- vaporizing a first metered amount of at least one pharmacologically active agent;
pulmonary delivering of the first metered amount to the subject from an inhaler device;
receiving at a controller associated with the inhaler device monitoring data indicative of at least one effect induced in the subject by the first metered amount; and
vaporizing, within a treatment regimen including the pulmonary delivering of the first metered amount, a second metered amount of at least one pharmacologically active agent, wherein a magnitude of the second metered amount is automatically controlled by the controller based at least partially on the monitoring data.
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Accused Products
Abstract
Provided herein is a method of pulmonary delivering to a subject at least one pharmacologically active agent being in a plant material, which is effected by pulmonary delivering the agent to the subject using a metered dose inhaler device that is configured to vaporize at least one pre-determined vaporized amount of the agent upon controllably heating the plant material, wherein the pre-determined vaporized amount is selected so as to achieve at least one pre-determined pharmacokinetic effect and/or at least one pre-determined pharmacodynamic effect induced by the agent in the subject.
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Citations
29 Claims
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1. A method of pulmonary delivering to a subject at least one pharmacologically active agent, the method comprising:
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vaporizing a first metered amount of at least one pharmacologically active agent; pulmonary delivering of the first metered amount to the subject from an inhaler device; receiving at a controller associated with the inhaler device monitoring data indicative of at least one effect induced in the subject by the first metered amount; and vaporizing, within a treatment regimen including the pulmonary delivering of the first metered amount, a second metered amount of at least one pharmacologically active agent, wherein a magnitude of the second metered amount is automatically controlled by the controller based at least partially on the monitoring data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A system for control of pulmonary delivery of pharmacologically active agent, the system comprising:
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an inhaler device operable for pulmonary delivery of at least one vaporized, pharmacologically active agent to a subject, the device including; a repository, configured to hold a substance comprising pharmacologically active agent; a power source, operable to deliver power to vaporize the pharmacologically active agent from the substance; and a controller, configured to control delivery of power to the substance, thereby vaporizing metered amounts of the pharmacologically active agent; and an interface operable to interact with the subject and obtain monitoring data indicative of at least one effect induced in the subject by a vaporized first metered amount of pharmacologically active agent delivered to the subject from the inhaler device; wherein the controller is configured to control delivery of power to the substance to vaporize a second metered amount of pharmacologically active agent for pulmonary delivery to the subject; and wherein the controller is configured to automatically control a magnitude of the second metered amount of pharmacologically active agent based at least partially on the monitoring data received from the interface. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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Specification