BIOSTABLE GLUCOSE PERMEABLE POLYMER
First Claim
1. A glucose sensing system comprising:
- a tubular housing having a first end and a second end, wherein;
the tubular housing comprises a polymeric composition formed by combining;
an isocyanate;
a polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol having an average molecular weight (Mr) of from about 600 to about 1200 Daltons; and
a terephthalate; and
the polymeric composition has a glucose permeability of at least 1×
10−
8 cm2/s at 37°
C. in phosphate buffered saline.
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Accused Products
Abstract
A new biostable glucose permeable polymer has been developed which is useful, for example, in implantable glucose sensors. This biostable glucose permeable polymer has a number of advantageous characteristics and, for example, does not undergo hydrolytic cleavage and degradation, thereby providing a composition that facilitates long term sensor stability in vivo. The versatile characteristics of this polymer allow it to be used in a variety of contexts, for example to form the body of an implantable glucose sensor. The invention includes the polymer composition, sensor systems formed from this polymer composition, and methods for making and using such sensor systems.
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Citations
20 Claims
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1. A glucose sensing system comprising:
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a tubular housing having a first end and a second end, wherein; the tubular housing comprises a polymeric composition formed by combining; an isocyanate; a polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol having an average molecular weight (Mr) of from about 600 to about 1200 Daltons; and a terephthalate; and the polymeric composition has a glucose permeability of at least 1×
10−
8 cm2/s at 37°
C. in phosphate buffered saline.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for making a glucose sensor comprising the steps of:
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(a) combining together an isocyanate, a polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol having an average molecular weight (Mr) of from about 600 to about 1200 Daltons; and
a terephthalate;(b) allowing the combination of (a) to form a polymeric composition having a glucose permeability of at least 1×
10−
8 cm2/s at 37°
C. in phosphate buffered saline;(c) using an extrusion process to mold the polymeric composition into a tubular housing having a first end and a second end. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A hydrophilic polyurea composition formed by combining:
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an isocyanate; a polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol having an average molecular weight (Mr) of from about 600 to about 1200 Daltons; and a terephthalate; wherein; the hydrophilic polyurea composition has a glucose permeability of at least 1×
10−
8 cm2/s at 37°
C. in phosphate buffered saline and the hydrophilic polyurea polymeric composition is biostable such that the tubular housing has less than a 5% weight loss after 7 days of implantation in vivo.
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Specification