Apparatus and Method for Preparing Cosmeceutical Ingredients Containing Epi-Dermal Delivery Mechanisms
First Claim
1. A method for the construction of cosmeceutically bioactive compositions including liposome or elastic niosome vesicle epi-dermal delivery vehicles, the method comprising:
- forming a solution or mixture of cosmeceutically benevolent phospholipids, the solution being a hydrophobic or hydrophilic, natural or synthetic ingredient, with an aqueous phase;
removing any constituent attributes of water-insolubility from the solution, while operating under mild conditions to preserve the activity of the labile biomolecules, the constituents of the solution that are either lipids or polymers all having in common that a final arrangement is governed by the nature of the initial components and a methodology used in their preparation;
loading the solution of the membrane lipid or niosome components and desired hydrophobic bio-actives into an organic solvent residing in a pressure reactor, the pressure reactor having been previously driven to a proper working temperature;
pressurizing the reactor with a large amount of compressed CO2 until reaching the proper low working pressure; and
depressurizing the resulting CO2-expanded solution over an aqueous phase to form vesicular conjugates, the resulting solution containing water soluble cationic or non-ionic surfactants and hydrophilic or hydrophobic bio-actives.
1 Assignment
0 Petitions
Accused Products
Abstract
The skin serves as a barrier that protects the body from the external environment and prevents water loss. This barrier function also prevents most hydrophilic or hydrophobic and large molecular weight ingredients (>500 kDa) from penetrating intact skin. Until recently, methods to increase stratum corneum permeability were generally not effective enough to make the stratum corneum so permeable that the barrier posed by the viable epidermis mattered. However, that has now changed with the development of the present embodiment'"'"'s physical methods and highly optimized chemical formulations, such that we revisited the permeability of the full epidermis with the example embodiment'"'"'s constructs and not focus only on the stratum corneum. This example embodiment therefore tests the hypothesis that the viable epidermis offers a significant permeability barrier to both small molecules and macromolecules that becomes the rate limiting step.
-
Citations
19 Claims
-
1. A method for the construction of cosmeceutically bioactive compositions including liposome or elastic niosome vesicle epi-dermal delivery vehicles, the method comprising:
-
forming a solution or mixture of cosmeceutically benevolent phospholipids, the solution being a hydrophobic or hydrophilic, natural or synthetic ingredient, with an aqueous phase; removing any constituent attributes of water-insolubility from the solution, while operating under mild conditions to preserve the activity of the labile biomolecules, the constituents of the solution that are either lipids or polymers all having in common that a final arrangement is governed by the nature of the initial components and a methodology used in their preparation; loading the solution of the membrane lipid or niosome components and desired hydrophobic bio-actives into an organic solvent residing in a pressure reactor, the pressure reactor having been previously driven to a proper working temperature; pressurizing the reactor with a large amount of compressed CO2 until reaching the proper low working pressure; and depressurizing the resulting CO2-expanded solution over an aqueous phase to form vesicular conjugates, the resulting solution containing water soluble cationic or non-ionic surfactants and hydrophilic or hydrophobic bio-actives. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
Specification