RINSE-OFF CHEMICAL MOUSSE CONTAINING BENZOYL PEROXIDE

• US 20170172972A1
• Filed: 03/27/2015
• Published: 06/22/2017
• Est. Priority Date: 03/28/2014
• Status: Active Grant

• Current Assignee: Galderma Research And Development Snc (Galderma Holding SA)
• Original Assignee: Galderma Research And Development Snc (Galderma Holding SA)
• Inventors: NADAU-FOURCADE, Karine, BUGE, Jean-Christophe
• Granted Patent: US 10,449,175 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2800/22 Gas releasing
• CPC Class Codes: A61K 2800/222 Effervescent
• CPC Class Codes: A61K 2800/882 Mixing prior to application
• CPC Class Codes: A61K 31/327 Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/38 Percompounds, e.g. peracids
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 9/0007 Effervescent A61K9/0065 takes precedence
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/12 Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/122 Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

A composition is described for a topical application, in the form of a rinse-off mousse, including no or only a small quantity of foaming surfactants. The composition can include a medium that is cosmetically or pharmaceutically compatible with a topical application, and benzoyl peroxide. The composition can also include at least one intermediate composition, at least one gas-generating agent, at least one agent activating the at least one gas-generating agent, and benzoyl peroxide. A kit or a single container with a plurality of compartments including this composition is also described.

Claims

1. A composition comprising benzoyl peroxide, wherein the composition is formulated as a rinse-off topical application in the form of a foam, comprising:

at least one intermediate composition,

at least one gas-generating agent,

at least one agent that activates the at least one gas-generating agent, and

benzoyl peroxide.

2. The composition as defined by claim 1, wherein the composition comprises:

at least one intermediate composition A that comprises the at least one agent that activates the at least one gas-generating agent,

at least one intermediate composition B that comprises the at least one gas-generating agent, and

benzoyl peroxide present in at least one of the at least one intermediate composition A and the at least one intermediate composition B.

3. The composition as defined by claim 1, wherein the benzoyl peroxide is present in the at least one intermediate composition A.

4. The composition as defined by claim 1, wherein the composition is self-foaming.

5. The composition as defined by claim 1, wherein the composition does not comprise any foaming surfactants or, if it comprises such surfactants, they are present in an amount less than or equal to 1% by weight, with respect to the weight of the total composition.

6. The composition as defined by claim 1, wherein the at least one gas generated from the at least one gas-generating agent is carbon dioxide (CO₂).

7. The composition as defined by claim 1, the at least one gas-generating agent is selected from the group consisting of sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate and their mixtures.

8. The composition as defined by claim 2, wherein the at least one gas-generating agent is present in the intermediate composition B in an amount ranging from 1% to 10% by weight, with respect to the weight of the intermediate composition B.

9. The composition as defined by claim 2, wherein the intermediate composition B exhibits a basic pH.

10. The composition as defined by claim 2, wherein the agent that activates the at least one gas-generating agent is selected from the group consisting of an acid, a partially salified polyacid salt, a buffer solution of weak acid and of its conjugate base, and mixtures of these compounds.

11. The composition as defined by claim 10, wherein the at least one agent that activates the at least one gas-generating agent is selected from the group consisting of citric acid, tartaric acid, malic acid, lactic acid, phosphoric acid and pyrophosphoric acid, and the salts of these acids.

12. The composition as defined by claim 11, wherein the at least one agent that activates the at least one gas-generating agent is a citric acid/sodium citrate buffer, alone or as a mixture with sodium phosphate and/or disodium pyrophosphate.

13. The composition as defined by claim 2, wherein the at least one agent that activates the at least one gas-generating agent is present in the intermediate composition A in an amount ranging from 0.001% to 95% by weight, with respect to the total weight of the intermediate composition A.

14. The composition as defined by claim 2, wherein the intermediate composition A exhibits an acidic pH.

15. The composition as defined by claim 2, wherein the intermediate composition A is in the form of a solution, a gel or an emulsion.

16. The composition as defined by claim 2, wherein the intermediate composition B is in the form of a solution, a gel or an emulsion.

17. The composition as defined by claim 2, wherein the composition is defined by mixing of the intermediate compositions A and B.

18. The composition as defined by claim 1, wherein the composition further comprises one or more active principles selected from the group consisting of emollients, humectants, agents for combating free radicals, anti-inflammatory agents, vitamins, depigmenting agents, antiacne agents, antiseborrheic agents, antifungal agents, keratolytic agents, sunscreens, slimming agents and skin-coloring agents.

19. The composition as defined by claim 1, wherein the composition further comprises one or more agents selected from the group consisting of dispersing agents, solubilizing agents, stabilizing agents, preservatives, fatty substances, thickening agents, dyes, fragrances, surfactants, gelling agents, complexing agents, neutralizing agents, foaming emulsifying agents, nonfoaming emulsifying agents, fillers, sequestering agents, reducing agents, odor maskers, plasticizing agents, softening agents, moisturizing agents, pigments, clays, inorganic fillers, inorganic colloids, polymers, proteins, pearlescent agents, waxes, oils, such as, for example, paraffins or silicones, fatty acids, solid esters of fatty alcohol or of fatty acids, gums and wetting agents.

20. A cosmetic method, comprising topically administering an effective amount of the composition as defined by claim 1, to the skin of an individual subject in need thereof.

21. A medicament comprising the composition as defined by claim 1, wherein the medicament is formulated for topical application to the skin.

22. A kit or single multicompartment container separately comprising at least two intermediate compositions:

an intermediate composition A comprising at least one agent that activates the at least one gas-generating agent, and

an intermediate composition B comprising at least one gas-generating agent; and

benzoyl peroxide being present in at least one of the intermediate compositions A and B, and wherein the intermediate compositions A and B are defined by claim 2.

23. The kit or single multicompartment container as defined by claim 22, wherein the kit or container are designed to simultaneously release doses of the intermediate compositions A and B according to a ratio by weight ranging from 2 doses of B per 1 dose of A to 2 doses of A per 1 dose of B.

24. The kit or single multicompartment container as defined by claim 22, wherein the kit or container are designed for mixing the intermediate compositions A and B in an A/B ratio by weight ranging from 0.5 to 2.

25. The composition as defined by claim 7, wherein the at least one gas generating agent is sodium bicarbonate.

26. The composition as defined by claim 9, wherein the at least one gas generating agent is present in an amount of from 2% to 8% by weight.

27. The composition as defined by claim 9, wherein the basic pH is from 7 to 12.

28. The composition as defined by claim 11, wherein the at least one activating agent is selected from the group consisting of a citric acid/sodium citrate buffer alone;

or phosphoric acid, sodium phosphate, and disodium pyrophosphate, alone or as a mixture with citric acid/sodium citrate buffer.

29. The composition as defined by claim 14, wherein the acidic pH is from 1 to 6.

30. The composition as defined by claim 15, wherein the at least one intermediate composition A is in the form of a gel.

31. The composition as defined by claim 16, wherein the at least one intermediate composition B is in the form of an emulsion.

32. The composition as defined by claim 19, wherein the oils are paraffins, silicones, fatty acids or solid esters of fatty alcohol or of fatty acids.

33. The composition as defined by claim 23, wherein the ratio by weight of intermediate compositions A and B is from 2 doses of B per 1 dose of A to 3 doses of A per 2 doses of B.

34. The composition as defined by claim 23, wherein the ratio by weight of intermediate compositions A and B is 1 dose of A per 1 dose of B.

35. The composition as defined by claim 24, wherein the A/B ratio is from 0.5 to 1.5.

36. The composition as defined by claim 24, wherein the A/B ratio is from 0.9 to 1.1.

37. The process as defined by claim 24, wherein the A/B ratio is 1.