NOVEL NON-INVASIVE METHOD FOR DIRECT DELIVERY OF THERAPEUTICS TO THE SPINAL CORD IN THE TREATMENT OF SPINAL CORD PATHOLOGY

• US 20170173307A1
• Filed: 12/20/2016
• Published: 06/22/2017
• Est. Priority Date: 12/22/2015
• Status: Active Application

• Current Assignee: University of South Florida (State University System of Florida)
• Original Assignee: US Department of Veterans Affairs (Government of the United States of America), University of South Florida (State University System of Florida)
• Inventors: Borlongan, Cesario Venturina, van Loveren, Harry Ronald, Garbuzova-Davis, Svitlana, Nelson, Peter Richard
• Granted Patent: US 10,285,935 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0085 Brain, e.g. brain implants; Spinal cord
• CPC Class Codes: A61M 2025/1015 having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

Most spinal cord therapies are administered systemically, with only a small portion of the therapeutic reaching the spinal cord. A novel method for delivering therapeutics directly to the spinal cord is provided. The method uses a duel-balloon catheter to isolate the microvasculature around a region of the spinal cord. Once isolated, one or more therapeutics are delivered directly to the spinal cord blood supply. This allows for smaller, safer therapeutic does to be utilized.

Claims

1. A method for treating a neurological disorder comprising:

advancing a catheter into a spinal cord artery, wherein the catheter comprises a plurality of balloons disposed on a tube, at least one injection port disposed on the tube and between the plurality of balloons;

inflating the plurality of balloons to isolate neurons effected by the neurological disorder;

administering a therapeutically effective amount of a composition through the at least one injection port to a patient in need thereof, wherein the composition is a motor neuron therapeutic;

allowing the composition to contact the effected neurons;

deflating the plurality of balloons; and

withdrawing the catheter.