×

SERUM ALBUMIN-BINDING FIBRONECTIN TYPE III DOMAINS

  • US 20170174748A1
  • Filed: 03/19/2015
  • Published: 06/22/2017
  • Est. Priority Date: 03/20/2014
  • Status: Active Grant
First Claim
Patent Images

1. A polypeptide comprising a fibronectin type III tenth domain (10Fn3) wherein the 10Fn3 domain comprises a) AB, BC, CD, DE, EF, and FG loops, b) a CD loop with an altered amino acid sequence relative to the sequence of the corresponding CD loop of the human 10Fn3 domain, c) wherein the polypeptide binds to human serum albumin with a KD of less than 500 nM, and d) wherein the 10Fn3 domain further binds to one or more of rhesus serum albumin, cynomolgus serum albumin, mouse serum albumin, and rat serum albumin with a KD of less than 500 nM, for example, less than 100 nM, or less than 10 nM.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×