SENSOR-UNSPECIFIC CALIBRATION METHODS AND SYSTEMS
First Claim
1. A method for real-time calibration of a glucose sensor for measuring the level of glucose in a body of a user, said sensor including physical sensor electronics, a microcontroller, and a working electrode, the method comprising:
- measuring, by said physical sensor electronics, the electrode current (Isig) for the working electrode;
obtaining a plurality of blood glucose (BG) values for said user, wherein said BG values include noise;
applying, by said microcontroller, an unscented Kalman filter to said plurality of BG values and determining an estimated calibration factor (CF) value based on said Isig and BG values; and
calculating, by said microcontroller, a calibrated sensor glucose (SG) value associated with said Isig based on said estimated CF value.
1 Assignment
0 Petitions
Accused Products
Abstract
An unscented Kalman filter is used to enable sensor calibration independently of the actual design of the subject sensors. By utilizing an unscented Kalman filter, an underlying calibration methodology is developed that is sensor-unspecific, such that a single calibration methodology and related systems may be used to calibrate various sensors, without the need to re-calculate a calibration factor for each specific sensor, and without the need to design a separate filtering mechanism to compensate for noise. In this way, various calibration inputs can be allowed to change over time without the need to change the codebase on which the calibration methodology otherwise operates. In multi-electrode systems, the methodology may incorporate a fusion algorithm to provide a single, fused sensor glucose value. The fusion algorithm may incorporate, and/or work in conjunction with, Electrochemical Impedance Spectroscopy (EIS) procedures.
-
Citations
26 Claims
-
1. A method for real-time calibration of a glucose sensor for measuring the level of glucose in a body of a user, said sensor including physical sensor electronics, a microcontroller, and a working electrode, the method comprising:
-
measuring, by said physical sensor electronics, the electrode current (Isig) for the working electrode; obtaining a plurality of blood glucose (BG) values for said user, wherein said BG values include noise; applying, by said microcontroller, an unscented Kalman filter to said plurality of BG values and determining an estimated calibration factor (CF) value based on said Isig and BG values; and calculating, by said microcontroller, a calibrated sensor glucose (SG) value associated with said Isig based on said estimated CF value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A program code storage device comprising:
-
a computer-readable medium; and computer-readable program code, stored on the computer-readable medium, the computer-readable program code having instructions which, when executed, cause a physical microcontroller to perform a method for real-time calibration of a glucose sensor for measuring the level of glucose in a body of a user, said sensor including physical sensor electronics, said physical microcontroller, and a working electrode, by; obtaining, from said physical sensor electronics, the electrode current (Isig) for the working electrode; obtaining a plurality of blood glucose (BG) values for said user, wherein said BG values include noise; applying an unscented Kalman filter to said plurality of BG values and determining an estimated calibration factor (CF) value based on said Isig and BG values; and calculating a calibrated sensor glucose (SG) value associated with said Isig based on said estimated CF value. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
Specification