ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS
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Abstract
Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.
22 Citations
22 Claims
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1-10. -10. (canceled)
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11. A device for measurement of a glucose concentration, the device comprising:
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a sensor configured to generate a signal indicative of a glucose concentration; and a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain comprises a copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, and wherein the copolymer comprises both hydrophilic and hydrophobic regions. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification