CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
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Abstract
Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.
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Citations
97 Claims
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1-77. -77. (canceled)
- 78. A compound of Formula I:
- 96. A method of inhibiting BRAF kinase activity of a cell, comprising administering to the cell an effective amount of a compound of Formula I:
Specification