GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
First Claim
1. A mammalian cell whose genome comprises a transgene comprising a gene segment comprising an exon encoding an immunoglobulin light chain variable (V) polypeptide and an immunoglobulin light chain non-coding element, wherein the V polypeptide is from a first species, wherein the non-coding element is from a second species, and wherein the exon encoding the V polypeptide replaces an immunoglobulin light chain V coding sequence of the second species.
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Abstract
The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
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Citations
20 Claims
- 1. A mammalian cell whose genome comprises a transgene comprising a gene segment comprising an exon encoding an immunoglobulin light chain variable (V) polypeptide and an immunoglobulin light chain non-coding element, wherein the V polypeptide is from a first species, wherein the non-coding element is from a second species, and wherein the exon encoding the V polypeptide replaces an immunoglobulin light chain V coding sequence of the second species.
Specification