NON-INVASIVE INTRAVASCULAR VOLUME INDEX MONITOR

• US 20170196464A1
• Filed: 12/22/2016
• Published: 07/13/2017
• Est. Priority Date: 09/15/2009
• Status: Active Grant

• Current Assignee: Masimo Corporation
• Original Assignee: Masimo Corporation
• Inventors: O'Reilly, Michael, Jansen, Paul Ronald
• Granted Patent: US 10,687,715 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/103 Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes A61B5/08 takes precedence; measuring aids for tailors A41H1/00; measuring instruments specially adapted for dentistry A61C19/04
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4878 Evaluating oedema
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B

Abstract

A non-invasive electronic patient monitor tracks one or more physiological parameters of a patient, such as intravascular volume index (IVI), extravascular volume index (EVI), total hemoglobin (SpHb), impedance, and/or weight. The patient monitor determines if one or more of the physiological parameters are within a predetermined range. The patient monitor activates an alarm if one or more of the physiological parameters are outside the predetermined range and indicates a patient can be experiencing edema and/or heart failure, or sepsis.

Claims

1-9. -9. (canceled)

10. A non-invasive multi-parameter patient monitoring system configured to determine a termination range for administering a diuretic, the non-invasive multi-parameter patient monitoring system comprising:

a first and second emitter configured to emit light of at least two wavelengths through tissue;

a detector configured to sense the light after it has passed through the tissue and to generate a signal indicative of the sensed light; and

a patient monitor comprising;

a sensor interface configured to receive the generated signal from the detector; and

a processor configured to;

determine a plurality of intravascular volume index (IVI) levels of a patient over a time period based at least in part on the received generated signal, and

determine a current IVI level,

wherein the patient monitor is configured to provide an indication that administration of the diuretic can be terminated based at least in part on a determination that the current IVI levels satisfies a threshold.

11. The system of claim 10, wherein the threshold is based at least in part on the plurality of IVI levels of the patient.

12. The system of claim 10, wherein the threshold is a predetermined threshold and wherein the predetermined threshold is approximately 61 for adult males and 64 for adult females.

13. The system of claim 10, wherein the threshold is a first threshold and the patient monitor is further configured to activate an alarm if the current IVI level satisfies a second threshold.

24. The system of claim 10, wherein the threshold is a patient-specific IVI threshold.

25. The system of claim 24, wherein the processor is further configured to determine the patient-specific IVI threshold based at least in part on the plurality of IVI levels.

26. The system of claim 10, wherein the plurality of IVI levels are determined based on an amount of light detected by the detector.

27. The system of claim 10, wherein the current IVI level satisfies the threshold when the current IVI level is at or below the threshold.

28. The system of claim 10, further comprising a host instrument configured to activate an alert based at least in part on the determination that the current IVI level satisfies the threshold.

29. The system of claim 10, wherein the processor is further configured to terminate administration of the diuretic based at least in part on the determination that the current IVI level satisfies the threshold.

30. The system of claim 10, wherein the processor is further configured to determine a progress of edema based at least in part on the plurality of IVI levels.

14-20. -20. (canceled)

21. A method for determining a termination range for administering a diuretic using a non-invasive multi-parameter patient monitor, the method comprising:

determining a plurality of intravascular volume index (IVI) levels of a patient over a time period based at least in part on an intensity signal indicative of IVI levels at a tissue site upon administration of a diuretic to the patient;

tracking the plurality of IVI levels of the patient using a non-invasive multi-parameter patient monitor; and

indicating that administration of the diuretic can be terminated based at least in part on a determination that a current IVI level satisfies a threshold.

31. The method of claim 21, further comprising determining the current IVI level.

32. The method of claim 21, further comprising terminating administration of the diuretic based at least in part on the determination that the current IVI level satisfies the threshold.

33. The method of claim 21, further comprising providing at indication that indicates administration of the diuretic can be terminated based at least in part on the determination that the current IVI level satisfies the threshold.

34. The method of claim 21, further comprising determining the threshold based at least in part on the plurality of IVI levels.

35. The method of claim 34, wherein the threshold is a first threshold, the method further comprising determining a second threshold based at least in part on the plurality of IVI levels.

36. The method of claim 35, further comprising activating an alarm based at least in part on a determination that the current IVI level satisfies a second threshold.

22. A non-invasive multi-parameter patient monitoring system configured to detect sepsis, the non-invasive multi-parameter patient monitoring system comprising:

a sensor having at least one emitter and a detector configured to attach to a tissue site, the detector providing a detector signal responsive to an intensity of energy from the emitter after it has passed through the tissue site; and

a patient monitor comprising;

a sensor interface configured to receive the detector signal from the sensor; and

a processor configured to;

determine a plurality of intravascular volume index (IVI) levels of a patient over a time period based at least in part on the received detector signal, and

detect and/or monitor a progress of sepsis based at least in part on the plurality of IVI levels.

23. The non-invasive multi-parameter patient monitoring system of claim 22, wherein the sensor is a first sensor and further comprising an impedance sensor configured to transmit impedance signals of the patient to the processor, wherein the processor is further configured to determine impedance levels of the patient and compute an extravascular volume index (EVI) using the impedance levels.