Serial Electrochemical Measurements of Blood Components

• US 20170196488A1
• Filed: 03/23/2017
• Published: 07/13/2017
• Est. Priority Date: 09/23/2014
• Status: Active Application

• Current Assignee: SRI International, Inc.
• Original Assignee: SRI International, Inc.
• Inventors: Hofius, Jonathan, Joseph, Jose P., Kothari, Manish, Garcia Kilroy, Pablo E.
• Application Number:
  US15/468,105
• Publication Number:
  US 20170196488A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

Devices, systems and methods for measuring, and configured to measure, a blood analyte continuously or at intervals, the device comprising at least a first set of analyte sensing sensor electrodes configured for making electrochemical measurements of the analyte, and at least a second set of biofouling prevention electrodes in operable proximity to, and configured to prevent biofouling of, the first set of electrodes.

Claims

1. A device configured to provide serial electrochemical measurements of blood components, the device comprising:

a pair of anode and cathode elongate sensor electrodes, each comprising a distal, terminal tip comprising a surface catalyst which catalyzes a chemical reduction-oxidation (redox) reaction of a blood analyte yielding an amperometric measurement of the analyte; and

a pair of anode and cathode elongate antifouling electrodes, each comprising an uninsulated, distal, terminal tip, between which an electrical current flows,

wherein the sensor and antifouling electrode tips are disposed on a planar surface, which may be flat or curved, and the antifouling electrode tips sufficiently surround one or both of the sensor electrode tips wherein when disposed in a vein the current causes chemical reactions in the blood around one or both of the sensor electrodes tips which reduces or prevents biofouling of the tip of one or both of the sensor electrodes.

2. The device of claim 1 wherein:

the planar surface is flat;

the sensor electrode tips are disposed on insulator pads;

the device is disposed in the lumen of a vein or artery;

the device is disposed in the lumen or on the surface of an implanted catheter;

the sensor electrode tips are separated by 1 nm to 1 mm;

the sensor and antifouling electrode tips are separated by 1 nm to 1 mm;

the biofouling prevention electrodes are at a distance from the sensor electrodes about or between 1000 um and 1 um;

the sensor electrodes are set in a pocket covered by one of the antifouling electrode tips patterned as a grid; and

/or

the sensor electrodes are set in a pocket covered by a first of the biofouling prevention electrodes and patterned as a grid with hole size smaller than the size of white blood cells.

3. The device of claim 1 configured for:

switching the polarity of the biofouling prevention electrodes;

measuring an analyte that is lactate or glucose; and

/or

preventing biofouling that is tissue or particle deposition, such as resulting from clot formation.

4. A method of using the device of claim 1 comprising (a) continually or continuously measuring impedance between the biofouling prevention electrodes and switching on higher voltages when higher impedance is sensed;

or (b) multiplying the concentration values read by the sensor electrodes by a constant dependent on the impedance between the biofouling prevention electrodes.

5. A device configured to provide serial electrochemical measurements of blood components, the device comprising:

a series of sensors, each sensor comprising a pair of elongate sensor electrodes, each comprising a distal, terminal tip comprising a surface catalyst which catalyzes a chemical reduction-oxidation (redox) reaction of a blood analyte yielding an amperometric measurement of the analyte at intervals, wherein the series is configured so that each of the sensors is exposed to blood for a predetermined time sufficiently limited to reduce or prevent biofouling of the tip of one or both of the sensor electrodes.

6. The device of claim 5, wherein the series of sensors is:

(a) printed on a rotatable strip within a catheter, rotated so that each of the sensors is exposed to blood for a predetermined time sufficiently limited to reduce or prevent biofouling of the tip of one or both of the sensor electrodes, wherein electrical connections to the tips are optionally made via brushes which stay stationary in one place while the strip slides beneath it;

(b) arranged on a strip configured to be inserted into a sheath with an opening such that only one of the series of sensors is exposed to blood at any one time;

(c) arranged on a side of a drum which rotates inside a sheath with an opening such that only one of the series of sensors is exposed to blood at any one time;

or

(d) compartmentalized to prevent the blood from coming in contact with more than one of the sensors at a time,

7. The device of claim 5 wherein:

the sheath and the sensor strip are inserted into a catheter;

the sensors are arranged in a parallel configuration;

the sensors are arranged so that they come in contact with a brush placed inside the sheath;

each sensor is compartmentalized so that only the sensors not under the opening of the sheath are not contaminated; and

/or

comprising multiple different analyte sensors in a single strip, such as lactate and glucose.

8. A method of using the device of claim 5 comprising taking with the device serial electrochemical measurements of blood components, wherein each of the sensors is exposed to blood for a predetermined time sufficiently limited to reduce or prevent biofouling of the tip of one or both of the sensor electrodes.