SYSTEMS AND METHODS FOR SPECTROSCOPY OF BIOLOGICAL TISSUE
First Claim
1. A Raman probe system to identify a plurality of tissues in a patient comprising:
- a fiber optic device that delivers and collects light;
a detector that detects the Raman scattered light and generates Raman spectral data; and
a data processor that processes the spectral data in combination with Raman basis spectra of a plurality of tissue components to identify one or more tissue regions in the patient.
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Accused Products
Abstract
The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.
7 Citations
29 Claims
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1. A Raman probe system to identify a plurality of tissues in a patient comprising:
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a fiber optic device that delivers and collects light; a detector that detects the Raman scattered light and generates Raman spectral data; and a data processor that processes the spectral data in combination with Raman basis spectra of a plurality of tissue components to identify one or more tissue regions in the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of identifying tissue in a patient comprising:
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processing Raman spectral data in a first region of a plurality of different regions in the patient using a plurality of basis spectra; decomposing the Raman spectral data into a plurality of correlation coefficients representing the first region into the plurality of basis spectra; comparing the plurality of correlation coefficients to identify tissue present in the first region; and recording the identity of the tissue in the first region. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification