COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

• US 20170202747A1
• Filed: 04/04/2017
• Published: 07/20/2017
• Est. Priority Date: 04/23/2015
• Status: Active Grant

• Current Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Inventors: Janders, Mike, Mumpower, Mariano, Lane, Benjamin R.
• Granted Patent: US 10,512,885 B2
• Time in Patent Office: Days
• CPC Class Codes: A61J 2200/70 Device provided with specific sensor or indicating means
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 2039/229 Stopcocks
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: B01F 2101/06 Mixing of food ingredients
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 2101/2202 Mixing compositions or mixers in the medical or veterinary field
• CPC Class Codes: B01F 2101/2204 Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
• CPC Class Codes: B01F 23/45 using flow mixing
• CPC Class Codes: B01F 23/451 by injecting one liquid into another
• CPC Class Codes: B01F 25/1051 of the mixing valve type
• CPC Class Codes: B01F 25/30 Injector mixers mixing by creating vortex flow B01F25/10
• CPC Class Codes: B01F 25/31 in conduits or tubes through which the main component flows
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 33/3017 Mixing chamber
• CPC Class Codes: B01F 33/84 Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
• CPC Class Codes: B01F 33/846 using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles
• CPC Class Codes: B01F 35/7176 using pumps
• CPC Class Codes: B01F 35/717611 : Peristaltic pumps
• CPC Class Codes: B01F 35/71805 : using valves, gates, orifices or openings
• CPC Class Codes: B65B 3/12 : mechanically, e.g. by pistons or pumps
• CPC Class Codes: F16K 11/085 : with cylindrical plug
• CPC Class Codes: F16K 11/0856 : having all the connecting conduits situated in more than one plane perpendicular to the axis of the plug
• CPC Class Codes: F16K 11/22 : with an actuating member for each valve, e.g. interconnected to form multiple-way valves
• CPC Class Codes: F16K 2099/0084 : Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 31/041 : for rotating valves F16K31/055 takes precedence
• CPC Class Codes: F16K 5/04 : with plugs having cylindrical surfaces; Packings therefor
• CPC Class Codes: F16K 5/0407 : with particular plug arrangements, e.g. particular shape or built-in means
• CPC Class Codes: F16K 5/0414 : Plug channel at 90 degrees to the inlet
• CPC Class Codes: F16K 99/0013 : Rotary valves
• CPC Class Codes: F16K 99/0042 : Electric operating means therefor

Abstract

An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. The junction structure can be configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. The junction structure can also include attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device at a location downstream of a pump system.

Claims

1. A pharmaceutical compounding device, comprising:

a first fluid source connected to a first valve;

a second fluid source connected to a second valve;

a third fluid source connected to a third valve;

a first line in fluid communication with an output of the first valve and extending to a micro pump mechanism;

a second line in fluid communication with an output of the second valve and an output of the third valve and extending to a macro pump mechanism;

a junction structure located downstream of both the micro pump mechanism and the macro pump mechanism and configured to join the first line with the second line such that fluid from the first fluid source is combined with fluid from the second fluid source and fluid from the third fluid source after passing by the micro pump mechanism and the macro pump mechanism.

2. The pharmaceutical compounding device of claim 1, wherein the first line has a cross sectional area taken normal to a longitudinal axis of the first line that is less than a cross sectional area of the second line taken normal to a longitudinal axis of the second line.

3. The pharmaceutical compounding device of claim 1, wherein the first line and second line are isolated from each other such that they are completely fluidly separated from each other until the junction structure.

4. The pharmaceutical compounding device of claim 1, further comprising:

a manifold including,

a micro channel configured to be connected to the first line, and

a macro channel configured to be connected to the second line, wherein a cross-sectional area taken normal to a longitudinal axis of the micro channel is smaller than a cross-sectional area taken normal to a longitudinal axis of the macro channel, and the manifold is located upstream of the micro pump mechanism and macro pump mechanism such that fluid passes through the manifold and then passes by the micro pump mechanism and macro pump mechanism.

5. The pharmaceutical compounding device of claim 4, wherein the first valve is located adjacent and in fluid communication with the micro channel of the manifold, and the second valve and third valve are located adjacent and in fluid communication with the macro channel of the manifold.

6. The pharmaceutical compounding device of claim 5, wherein an inner diameter of the micro channel is equal to an inner diameter of the macro channel.

7. The pharmaceutical compounding device of claim 1, further comprising:

a housing that supports the macro pump mechanism and the micro pump mechanism, wherein

the junction structure includes two inlet ports each configured for attachment to a respective one of the first line and second line, and an attachment structure configured to attach the junction structure to the housing.

8. The pharmaceutical compounding device of claim 1, wherein the junction structure includes a mixing chamber and an outlet port.

9. The pharmaceutical compounding device of claim 1, further comprising:

a housing that supports the macro pump mechanism and the micro pump mechanism, wherein

the junction structure includes a standoff structure extending from a lower surface of the junction structure and configured to space the junction structure from a surface of the housing to which the junction structure is to be attached.

10. A transfer set kit for use with a pharmaceutical compounding device, comprising:

a plurality of micro input lines each having a cross sectional area taken normal to a longitudinal axis of each respective one of the plurality of micro input lines;

a plurality of macro input lines each having a cross sectional area taken normal to a longitudinal axis of each respective one of the plurality of macro input lines, each of the macro input lines separate and distinct from each of the micro input lines such that fluid within each of the micro input lines is isolated from fluid within each of the macro input lines;

a manifold including a micro channel and a macro channel separate from and in fluid isolation from the micro channel, the manifold including a plurality of micro ports each configured to be connected to a respective one of the plurality of micro input lines, and a plurality of macro ports each configured to be connected to a respective one of the plurality of macro input lines, wherein the cross sectional area of each of the micro input lines is less than the cross sectional area of each of the macro input lines;

an output micro input line configured to be connected to a micro output port of the micro channel;

an output macro input line configured to be connected to a macro output port of the macro channel; and

a junction structure configured to join the output micro input line with the output macro input line.

11. The transfer set kit of claim 10, further comprising:

at least one junction structure clip configured to connect the junction structure to a housing of the compounding device.

12. The transfer set kit of claim 10, wherein the junction structure includes an attachment structure for fluid connection to a final container.

13. The transfer set kit of claim 10, wherein the junction structure includes a mixing chamber and an outlet port.

14. The transfer set kit of claim 10, wherein the junction structure includes a standoff structure extending from a lower surface of the junction structure and configured to space the junction structure from a surface of the compounding device to which the junction structure is to be attached.

15. The transfer set kit of claim 14, further comprising a junction output line extending from an output port of the junction structure, wherein the standoff structure is configured such that each of the output micro input line, the output macro input line are substantially contained in a common plane, and the junction output line extends away from the junction structure in the common plane.