SYSTEM AND METHOD FOR INTRAOCULAR PRESSURE SENSING

• US 20170209045A1
• Filed: 01/26/2017
• Published: 07/27/2017
• Est. Priority Date: 01/26/2016
• Status: Active Application

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology, Regents of the University of California (University of California)
• Inventors: Choo, Hyuck, Lee, Jeongoen, Sretavan, David W.
• Application Number:
  US15/417,128
• Publication Number:
  US 20170209045A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers

Abstract

IOP sensor and system for measuring intraocular pressure are disclosed herein. Examples embodiments of the IOP sensor can include: a chamber having a first wall and a second wall opposing the first wall; a first array of photonic components disposed inside of the chamber; a raised portion located within the chamber on a surface of the second wall; at least one side wall separating the first and second walls; and a layer of anti-reflective coating within the chamber.

Claims

1. An intraocular pressure sensing system comprising:

a chamber having a first wall and a second wall opposing the first wall, wherein the chamber comprises an anti-reflection layer;

a first array of photonic components disposed inside of the chamber; and

at least one sidewall separating the first and second walls.

2. The intraocular pressure sensing system of claim 1, further comprising:

apparatus having a light source configured to shine light into the chamber;

an optical spectrometer configured to receive light reflected from the first array of photonic components inside of the chamber and to output a signal indicative of a resonance spectrum upon receiving the reflected light;

a processor coupled to the optical spectrometer; and

non-transitory memory on which is stored a plurality of instructions that, when executed, cause the processor to determine the intraocular pressure based on the signal indicative of a resonance spectrum.

3. The intraocular pressure sensing system of claim 1, wherein the first wall comprises a flexible membrane.

4. The intraocular pressure sensing system of claim 3, wherein the first array of photonic components is disposed on a first surface of the flexible membrane.

5. The intraocular pressure sensing system of claim 3, wherein the flexible membrane comprises a silicon nitride membrane.

6. The intraocular pressure sensing system of claim 1, further comprising a raised portion located within the chamber on a surface of the second wall.

7. The intraocular pressure sensing system of claim 6, wherein the first array of photonic components is disposed on a surface of the raised portion.

8. The intraocular pressure sensing system of claim 7, further comprising a second array of photonic components disposed on a first surface of the first wall.

9. The intraocular pressure sensing system of claim 7, further comprising an air gap between the first surface of the first wall and the surface of the raised portion.

10. The intraocular pressure sensing system of claim 9, wherein the air gap has a thickness range of 5-10 μ

m.

11. The intraocular pressure sensing system of claim 1, further comprising a raised section along a perimeter of the first wall and located on a second surface of the first wall, the second surface being opposed and parallel to the first surface of the first wall.

12. The intraocular pressure sensing system of claim 11, further comprising a second layer of anti-reflection coating on a surface of the raised section that is parallel to the first wall.

13. The intraocular pressure sensing system of claim 1, wherein the first array of photonic components comprises photonic components with a hemispherical shape.

14. The intraocular pressure sensing system of claim 13, wherein each photonic component has a diameter between 100-1000 nanometers and a component-to-component pitch between 500-1500 nanometers.

15. The intraocular pressure sensing system of claim 1, wherein the first array of photonic components comprises a 200 μ

m×

200 μ

m array of photonic components.

16. The intraocular pressure sensing system of claim 2, wherein the plurality of instructions, when executed, cause the processor to determine the intraocular pressure by:

application of a denoising and low pass filter to the resonance spectrum received from the optical spectrometer;

detection of a variation in the resonance spectrum; and

extraction of a pressure reading from the detected variation with a neural network algorithm, wherein the neural network algorithm comprises a feed forward network.

21. The intraocular pressure sensing system of claim 1, wherein the anti-reflection layer is located between the first wall and the at least one sidewall.

22. The intraocular pressure sensing system of claim 1, wherein the anti-reflection layer is located on a surface of the second wall parallel to the first wall.

23. The intraocular pressure sensing system of claim 1, wherein the anti-reflection layer is located on a side surface of the raised portion, the side surface being perpendicular to the second wall.

25. The intraocular pressure sensing system of claim 1, further comprising:

apparatus having a light source configured to shine light into the chamber;

an optical spectrometer configured to receive light reflected from the first array of photonic components inside of the chamber and to output a signal indicative of a resonance spectrum upon receiving the reflected light;

a processor coupled to the optical spectrometer; and

non-transitory memory on which is stored a plurality of instructions that, when executed, cause the processor to;

send the output signal indicative of the resonance spectrum to a remote server for intraocular pressure analysis;

receive an intraocular pressure reading in response to the sending the output signal; and

displaying the intraocular pressure reading on a display area of the apparatus.

17-20. -20. (canceled)

24. (canceled)

26-38. -38. (canceled)