NASAL DELIVERY

• US 20170216540A1
• Filed: 09/13/2016
• Published: 08/03/2017
• Est. Priority Date: 11/15/2000
• Status: Abandoned Application

• Current Assignee: OptiNose AS (OptiNose, Inc.)
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle
• Application Number:
  US15/263,630
• Publication Number:
  US 20170216540A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/006 operated by applying mechanical pressure to the liquid to be sprayed or atomised
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/071 hand operated
• CPC Class Codes: A61M 2205/073 : Syringe, piston type
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2210/0668 : Middle ear
• CPC Class Codes: A61M 2230/43 : Composition of exhalation

Abstract

A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.

Claims

1-17. -17. (canceled)

18. A nasal delivery device comprising:

a housing;

a nosepiece for fitting in a nostril of a subject, the nosepiece connected to the housing;

a substance supply unit configured to deliver a metered dose of a substance through the nosepiece;

a flow resistor; and

a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the nosepiece.

19. The nasal delivery device of claim 18, wherein the flexible member is a resilient membrane.

20. The nasal delivery device of claim 18, wherein the substance supply unit further comprises a biasing element and a release mechanism.

21. The nasal delivery device of claim 20, wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.

22. The nasal delivery device of claim 18, further comprising a nozzle, wherein the nozzle is fluidly connected to the substance supply unit and is configured to provide an aerosol spray through the nosepiece.

23. The nasal delivery device of claim 18, wherein the substance supply unit comprises a mechanical delivery pump.

24. The nasal delivery device of claim 18, wherein the substance is a liquid or a powder.

25. The nasal delivery device of claim 18, wherein the substance supply unit comprises a nebulizer.

26. A nasal delivery device comprising:

a housing;

a nosepiece for fitting in a nostril of a subject, the nosepiece connected to the housing;

a substance supply unit configured to deliver a metered dose of a substance through the nosepiece;

a mouthpiece through which the subject exhales to actuate the substance supply unit, the mouthpiece fluidly connected to the housing;

a flow resistor; and

a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the nosepiece.

27. The nasal delivery device of claim 26, wherein the mouthpiece is in fluid communication with the chamber.

28. The nasal delivery device of claim 26, wherein the flexible member is a resilient membrane.

29. The nasal delivery device of claim 26, wherein the substance supply unit further comprises a biasing element and a release mechanism.

30. The nasal delivery device of claim 29, wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.

31. The nasal delivery device of claim 26, wherein the substance is a liquid or a powder.

32. A nasal delivery device comprising:

a housing;

a first nosepiece for fitting in a nostril of a subject, the first nosepiece connected to the housing;

a substance supply unit configured to deliver a metered dose of a substance through the first nosepiece;

a mouthpiece through which the subject exhales to actuate the substance supply unit, the mouthpiece fluidly connected to the housing;

a flow resistor, comprising a progressive flow resistor in fluid communication with a second nosepiece; and

a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the first nosepiece.

33. The nasal delivery device of claim 32, wherein the progressive flow resistor, when inflated, indicates operation of the nasal delivery device.

34. The nasal delivery device of claim 32, wherein the flexible member is a resilient membrane.

35. The nasal delivery device of claim 32, wherein the substance supply unit further comprises a biasing element and a release mechanism.

36. The nasal delivery device of claim 35, wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.

37. The nasal delivery device of claim 32, wherein the substance is a liquid or a powder.