NANOPARTICULATE ASSISTED NANOSCALE MOLECULAR IMAGING BY MASS SPECTROMETRY
First Claim
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1. An instrument for the preparation of a sample, the instrument comprising:
- a first differentially-pumped vacuum region comprising a nanoparticulate beam source configured to create and accelerate a nanoparticulate ion beam;
a second differentially-pumped vacuum region coupled to the first differentially-pumped vacuum region for accelerating and focusing the nanoparticulate ion beam;
a third differentially-pumped vacuum region coupled to the second differentially-pumped vacuum region, wherein the third differentially-pumped vacuum region comprises a sample stage for positioning the sample for implantation in the sample with nanoparticles from the nanoparticulate ion beam; and
at least one deposition source coupled to at least one of the first differentially-pumped vacuum region, second differentially-pumped vacuum region, and third differentially-pumped vacuum region.
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Abstract
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
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Citations
34 Claims
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1. An instrument for the preparation of a sample, the instrument comprising:
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a first differentially-pumped vacuum region comprising a nanoparticulate beam source configured to create and accelerate a nanoparticulate ion beam; a second differentially-pumped vacuum region coupled to the first differentially-pumped vacuum region for accelerating and focusing the nanoparticulate ion beam; a third differentially-pumped vacuum region coupled to the second differentially-pumped vacuum region, wherein the third differentially-pumped vacuum region comprises a sample stage for positioning the sample for implantation in the sample with nanoparticles from the nanoparticulate ion beam; and at least one deposition source coupled to at least one of the first differentially-pumped vacuum region, second differentially-pumped vacuum region, and third differentially-pumped vacuum region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method, comprising:
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generating a nanoparticulate ion beam; modifying nanoparticles of the nanoparticulate ion beam to form modified nanoparticles; and implanting the modified nanoparticles of the nanoparticulate ion beam in a sample. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method for the collection of analytical data from a sample, the method comprising:
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adding matrix to the sample with nanoparticles of a nanofocused nanoparticulate beam source; co-depositing material from a deposition source on the sample with the nanoparticles from the nanoparticulate ion beam; analyzing at least a portion of the sample having the matrix and the co-deposited material with a fluorescence or Raman spectrometer; thereafter desorbing chemical species from the sample using a nanofocused primary particle beam source; and analyzing at least a portion of the desorbed chemical species. - View Dependent Claims (29, 30, 31, 32, 33, 34)
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Specification