SYSTEM AND/OR METHOD FOR GLUCOSE SENSOR CALIBRATION
First Claim
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1. A method comprising:
- obtaining samples of an electrical signal generated by a sensor, said samples having sample values responsive to a blood-glucose concentration in a patient;
obtaining blood glucose reference measurement values, said blood glucose reference measurement values being indicative of said blood-glucose concentration;
temporally associating at least some of said sample values with at least some of said blood glucose reference measurement values;
for at least one of said sample values temporally associated with at least one of said blood glucose reference measurement values, weighting said at least one of said temporally associated sample values based, at least in part, on a measure of statistical dispersion of said electrical signal, said measure of statistical dispersion of said electrical signal being determined based, at least in part, on said at least one of said blood glucose reference measurement values;
determining one or more parameters of an estimator of said blood-glucose concentration based, at least in part, on said weighted sample values; and
generating a control signal to a pump to affect infusion of a substance to said patient based, at least in part, on said determined one or more parameters of said estimator of said blood-glucose concentration.
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Abstract
The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.
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Citations
20 Claims
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1. A method comprising:
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obtaining samples of an electrical signal generated by a sensor, said samples having sample values responsive to a blood-glucose concentration in a patient; obtaining blood glucose reference measurement values, said blood glucose reference measurement values being indicative of said blood-glucose concentration; temporally associating at least some of said sample values with at least some of said blood glucose reference measurement values; for at least one of said sample values temporally associated with at least one of said blood glucose reference measurement values, weighting said at least one of said temporally associated sample values based, at least in part, on a measure of statistical dispersion of said electrical signal, said measure of statistical dispersion of said electrical signal being determined based, at least in part, on said at least one of said blood glucose reference measurement values; determining one or more parameters of an estimator of said blood-glucose concentration based, at least in part, on said weighted sample values; and generating a control signal to a pump to affect infusion of a substance to said patient based, at least in part, on said determined one or more parameters of said estimator of said blood-glucose concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An apparatus comprising:
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a sensor to generate one or more sensor signals responsive to a blood glucose concentration in a body; an infusion pump; and a computing platform to; obtain samples of said one or more sensor signals; obtain blood glucose reference measurement values, said blood glucose reference measurement values being indicative of said blood-glucose concentration; temporally associate at least some of said sample values with at least some of said blood glucose reference measurement values; for at least one of said sample values temporally associated with at least one of said blood glucose reference measurement values, weight said at least one of said temporally associated sample values based, at least in part, on a measure of statistical dispersion of said electrical signal, said measure of statistical dispersion of said electrical signal being determined based, at least in part, on said at least one of said blood glucose reference measurement values; determine one or more parameters of an estimator of said blood-glucose concentration based, at least in part, on said weighted sample values; and generate a control signal to said infusion pump to infuse a substance to said body based, at least in part, on said determined one or more parameters of said estimator of said blood-glucose concentration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification