SYNCHRONIZED DUAL MODE OCT SYSTEM

• US 20170234675A1
• Filed: 10/08/2015
• Published: 08/17/2017
• Est. Priority Date: 07/29/2014
• Status: Active Grant

• Current Assignee: Collage Medical Imaging Ltd.
• Original Assignee: Collage Medical Imaging Ltd.
• Inventors: ZVULONI, Roni, IDDAN, Gavriel J.
• Granted Patent: US 9,958,253 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/7214 using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01B 2290/45 Multiple detectors for detecting interferometer signals
• CPC Class Codes: G01B 9/02004 using frequency scans
• CPC Class Codes: G01B 9/02014 by using pulsed light
• CPC Class Codes: G01B 9/02027 Two or more interferometric channels or interferometers
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/02069 Synchronization of light source or manipulator and detector
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01J 3/36 Investigating two or more bands of a spectrum by separate detectors
• CPC Class Codes: G01J 3/4531 Devices without moving parts
• CPC Class Codes: G01N 2021/1787 Tomographic, i.e. computerised reconstruction from projective measurements
• CPC Class Codes: G01N 2021/399 Diode laser
• CPC Class Codes: G01N 21/39 using tunable lasers
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

The present application in some embodiments relates to methods for reducing noise and/or clutter when measuring a spectrum, particularly but not only for OCT imaging. In some embodiments a light source is synchronized with a detector. For example a narrow band light source is synchronized with a narrow band detector. For example, the light source may scan over multiple frequency bands and/or the detector may be tuned to a frequency band synergetic to the band of the light source. For example the light source and detector may be tuned to overlapping narrow bands. Optionally the detector has a sensor set for each frequency band. Optionally some sensor sets are individually resettable. For example each set may have a reset circuit. For example, a sensor set for a band not currently being measured is deactivated.

Claims

1. A system comprising:

an adjustable frequency narrow band light source;

a beam splitter for dividing light from said light source along a sample and a reference path;

an adjustable frequency narrow band detector positioned to receive light from both the sample and the reference paths; and

a controller configured for;

controlling a frequency and bandwidth of said light source to emit light pulses over time in a succession of narrow frequency bands,

synchronizing said detector to said light source by tuning said detector to be sensitive to a respective narrow reception band that overlaps each narrow band of said succession of narrow bands when said each narrow band reaches said detector, and

analyzing the output from said detector to estimate a reflectance distribution along a depth profile of the sample.

2. The system of claim 1, wherein said adjustable frequency narrow band light source includes a vertical-cavity surface-emitting laser (VCSEL).

3. The system of claim 1, wherein said adjustable frequency narrow band light source emits a coherent light.

4. The system of claim 1, wherein said adjustable frequency narrow band detector includes:

a light deflector having a frequency dependent angle of deflection, said light deflector receiving an incident light beam and producing a deflected beam;

a sensor array including a plurality of sensors, each of said plurality of sensors positioned, to receive said deflected beam at a different respective deflection angle corresponding to a respective narrow frequency band;

said each sensor incremented from a base state to an exposed state by exposure to said deflected light of said respective narrow frequency band;

said controller further configured for adjusting a frequency sensitivity of said detector to said narrow reception band by activating at least one target sensor of said plurality of sensors;

said target sensor positioned to receive said deflected light corresponding to said narrow reception band;

said controller further configured for setting to said base state at least one other sensor while said target sensor is activated;

said other sensor neighboring to said target sensor.

5. The system of claim 4, further comprising:

a plurality of reset circuits, each circuit of said plurality of reset circuits for setting at least one proper subset of said plurality of sensors to said base state, and wherein said each reset circuit is operationally controlled by said controller.

6. The system of claim 4, further comprising:

at least one reset circuit for setting at least some of said plurality of sensors to said base state, and

at least one switch for connecting a proper subset of said plurality of sensors to said reset circuit wherein said at least one switch is operationally connected to and controlled by said controller.

7. The system of claim 5, wherein each circuit of said plurality of reset circuits connects said proper subset of said plurality of sensors to a ground.

8. The system of claim 1, wherein said light source is configured to emit a narrow band light having a bandwidth less than 1/10 the bandwidth of a full spectrum of said light source.

10. The system of claim 1, wherein said detector is configured to have a narrow band sensitivity having a bandwidth less than 1/10 the bandwidth of a full spectrum sensitivity of said detector.

9. (canceled)

11. (canceled)

12. A method comprising:

emitting light over a plurality of narrow illumination wave-bands, each narrow illumination wave-band emitted at a specified time and reaching a detector at a corresponding time;

dividing said light along a sample path and a reference path;

receiving light from both the sample and the reference paths at a detector;

synchronizing a frequency sensitivity band of said detector at said corresponding time to overlap said each illumination wave-band at said specified time and

analyzing the output from said detector to derive a depth distribution of reflectance of a sample.

14. The method claim 12, wherein emitting is of a narrow band light having a bandwidth less than 1/10 the bandwidth of a full spectrum of said light source.

16. The method of claim 12, wherein said synchronizing includes configuring said detector with said sensitivity band having a bandwidth less than 1/10 the bandwidth of a full spectrum sensitivity of said detector.

17. The method of claim 12, wherein said synchronizing includes configuring said detector with said sensitivity band having a bandwidth less than 5 nm.

18. The method of claim 12, wherein said detector includes a sensor array, said sensor array including a plurality of sensors, the method further comprising:

deflecting said signal at a frequency dependent angle;

activating a first sensor of said plurality of sensors said first sensor positioned to be exposed to light deflected at an angle corresponding to said sensitivity band;

setting a second sensor to a base state while said first sensor is in said activated state.

19. The method of claim 18, wherein said setting includes connecting said second sensor to a reset circuit.

20. The method of claim 18, wherein said setting includes connecting said second sensor to a ground.

21. The method of claim 18, further comprising:

exciting said first sensor from said base state to an excited state according to a light intensity in said sensitivity band after said setting.

22. The method of claim 18, further comprising:

also exciting said second sensor from said base state to an excited state according to a light intensity in another frequency band after said setting.

23. The method of claim 22, further comprising:

resetting said first sensor to said base state simultaneous to said also exciting.

24. The method of claim 12, wherein said specified time and said corresponding time are substantially simultaneous.

13. (canceled)

15. (canceled)

25-50. -50. (canceled)