COMPOSITIONS AND METHODS FOR TREATING B-LYMPHOID MALIGNANCIES
First Claim
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1. A method of inhibiting a B-cell neoplasm in a subject in need thereof, wherein said B-cell neoplasm expresses a CD19 isoform, said method comprising administering to the subject a therapeutically effective amount of at least one Src family kinase (SFK) inhibitor and/or at least one chimeric antigen receptor-modified T cell which recognizes the ectodomain of said CD19 isoform, CD20, or CD22.
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Abstract
Compositions and methods for inhibiting, treating, and/or preventing a B-cell neoplasm are provided.
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14 Claims
- 1. A method of inhibiting a B-cell neoplasm in a subject in need thereof, wherein said B-cell neoplasm expresses a CD19 isoform, said method comprising administering to the subject a therapeutically effective amount of at least one Src family kinase (SFK) inhibitor and/or at least one chimeric antigen receptor-modified T cell which recognizes the ectodomain of said CD19 isoform, CD20, or CD22.
Specification