COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE

• US 20170240557A1
• Filed: 02/23/2017
• Published: 08/24/2017
• Est. Priority Date: 02/24/2016
• Status: Active Grant

• Current Assignee: EWHA University-Industry Collaboration Foundation (Ewha Womans University)
• Original Assignee: EWHA University-Industry Collaboration Foundation (Ewha Womans University)
• Inventors: Yoon, Juyoung, Zhou, Xin, Hu, Ying, Chen, Liyan
• Granted Patent: US 10,640,513 B2
• Time in Patent Office: Days
• CPC Class Codes: C07D 209/14 Radicals substituted by nitrogen atoms, not forming part of a nitro radical
• CPC Class Codes: C07D 221/14 Aza-phenalenes, e.g. 1,8-naphthalimide
• CPC Class Codes: C07D 271/12 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 311/88 Nitrogen atoms
• CPC Class Codes: C07D 491/107 with only one oxygen atom as ring hetero atom in the oxygen-containing ring
• CPC Class Codes: G01N 2021/7783 Transmission, loss
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 31/223 for investigating presence of specific gases or aerosols G01N31/221, G01N31/222 take precedence; actuation of fire alarm by presence of smoke or gases G08B17/10

Abstract

The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.

Claims

1. A compound represented by formula 1 below:

2. The compound according to claim 1, wherein R1 is —

H, C1-5 straight or branched alkyl, C1-5 straight or branched alkoxy, or 4-6 membered heterocycloalkyl containing 2-3 hetero atoms selected from the group consisting of N, O, and S.

3. The compound according to claim 1, wherein R1 is C1-4 straight or branched alkyl, or 6 membered heterocycloalkyl containing 2-3 hetero atoms selected from the group consisting of N, O, and S.

4. The compound according to claim 1, wherein the compound represented by formula 1 above is the compound selected from the group consisting of the following compounds:

5. A method for preparing the compound represented by formula 1 of claim 1 containing the step of reacting the compound represented by A-LG with the compound represented by formula 2 to give the compound represented by formula 1 (step 1) as shown in the below reaction formula 1:

6. A composition for detecting phosgene comprising the compound of claim 1.

7. A composition for the detection DCP (diethyl chlorophosphate) comprising the compound of claim 1.

8. A kit for the detection of one or more compounds selected from the group consisting of phosgene and DCP (diethyl chlorophosphate) comprising the compound of claim 1.

9. The kit according to claim 8, wherein the kit is to detect the changes of fluorescence or absorbance caused by the changes of π

-conjugation system of the compound of claim 1, which is resulted from the nucleophilic attack of phenylenediamine included in the compound of claim 1 against phosgene or DCP (diethyl chlorophosphate).

10. A method for the detection of one or more compounds selected from the group consisting of phosgene and DCP (diethyl chlorophosphate) comprising the following steps:

contacting the kit of claim 8 with the sample to be analyzed (step

     1); and

evaluating the changes of fluorescence or absorption properties of the kit of claim 8 after the contact of step 1 (step

     2).