Capsule Coating for Image Capture Control

• US 20170245742A1
• Filed: 12/04/2014
• Published: 08/31/2017
• Est. Priority Date: 12/04/2014
• Status: Abandoned Application

• Current Assignee: CapsoVision, Inc.
• Original Assignee: CapsoVision, Inc., Mark Hadley, Mikael Trollsas
• Inventors: HADLEY, Mark, TROLLSAS, Mikael
• Application Number:
  US15/515,809
• Publication Number:
  US 20170245742A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 1/00009 of image signals during a use of endoscope
• CPC Class Codes: A61B 1/00036 Means for power saving, e.g. sleeping mode
• CPC Class Codes: A61B 1/00096 Optical elements
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/045 Control thereof
• CPC Class Codes: A61B 1/05 characterised by the image sensor, e.g. camera, being in the distal end portion
• CPC Class Codes: A61B 1/0655 Control therefor
• CPC Class Codes: A61B 2562/162 Capsule shaped sensor housings, e.g. for swallowing or implantation
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61K 9/48 Preparations in capsules, e.g. of gelatin, of chocolate A61K9/0004 takes precedence; bite capsules A61K9/0056
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: H04N 23/555 for picking-up images in sites, inaccessible due to their dimensions or hazardous conditions, e.g. endoscopes or borescopes

Abstract

A capsule device and a method for the capsule device remain in a very low power state and monitor whether it enters a desired section of the gastrointestinal track. The capsule device is coated with an enteric material that is expected to dissolve after it enters the small bowel. In the monitoring state, the capsule device captures a first image using the camera and the light source at a first frame rate substantially below a target frame rate. The capsule device compares first information related to the first image with second information related to a coating image corresponding to the coating. If the first information does not matches the second information, the capsule device declares that the coating has dissolved and the capsule device configures the camera to capture third images at the target rate after declaring that the coating has dissolved.

Claims

1. A method of image capture control for a capsule device with a camera and a light source enclosed in a capsule housing, wherein a coating on outer surface of the housing to cover a field of view of the camera and the coating is dissolvable depending on a factor of an intraluminal environment, the method comprising:

administering the capsule device to a living subject;

determining a first image corresponding to a coating image that the capsule device captures with the coating present;

capturing a second image using the camera and the light source at a first frame rate substantially below a target frame rate;

determining whether first information related to the first image matches with second information related to the second image;

if the first information matches with the second information, repeating said capturing the second image and said determining whether the first information related to the first image matches with the second information related to the coating image; and

if the first information does not matches with the second information, configuring the camera to capture third images at the target rate after said declaring that the coating has dissolved.

2. The method of claim 1, wherein said determining whether the first information related to the first image matches with the second information related to the second image is performed using a processing unit inside the capsule device.

3. The method of claim 1, wherein said determining whether the first information related to the first image matches with the second information related to the second image is performed outside the capsule device.

4. The method of claim 1, wherein said determining the first image corresponds to capturing one initial image using the camera and the light source after the capsule device is administered.

5. The method of claim 4, wherein the first image is captured at reduced resolution or cropped size.

6. The method of claim 4, wherein the first image is captured with reduced luminous energy from the light source.

7. The method of claim 1, wherein the first information and the second information are derived based on partial samples of the first image and the second image respectively.

8. The method of claim 1, wherein the first information and the second information correspond to color, brightness, or contents of the first image and the second image respectively.

9. The method of claim 8, wherein said determining whether the first information related to the first image matches with the second information related to the second image is based on an average or median value of the color or the brightness of the first image and the second image respectively.

10. The method of claim 1, wherein the coating image corresponding to the coating includes a blue, green or white area.

11. The method of claim 1, wherein the first information and the second information are determined based on selected samples at fixed locations of underlying images respectively.

12. The method of claim 11, wherein the selected samples are converted to binary data;

the selected samples of the first image are compared with the selected samples of the second image on a sample-by-sample basis to obtain a count of matched samples; and

the count of matched samples is used to determine whether the coating has dissolved.

13. The method of claim 1, wherein, after said declaring that the coating is dissolved, the camera is configured to wait for a period of time before said capturing the third images at the target rate.

14. The method of claim 1, wherein the first image is determined using a sample capsule device having a same-type camera coated with a same-type coating and a same-type light source as the capsule device.

15. The method of claim 1, wherein the capsule device is configured to wait for a period of time before said capturing the first image using the camera and the light source.

16. A capsule device adapted to be swallowed by a patient for imaging gastrointestinal (GI) track of the patient, the capsule device comprising:

an image sensor for capturing images projected on the image sensor;

a light source;

a capsule housing to enclose the image sensor and the light source;

a coating on outer surface of the capsule housing covering at least an area corresponding a field of view to be imaged by the sensor, wherein the coating is dissolvable depending on a factor of an intraluminal environment; and

a processing unit configured to;

(a) determine a first image corresponding to a coating image that the image sensor captures with the coating present;

(b) capture a second image using the image sensor and the light source at a first frame rate substantially below a target frame rate; and

(c) determine whether first information related to the first image matches with second information related to the second image;

(d) if the first information related to the first image matches with the second information related to the second image, repeat steps (a) to (c); and

(e) if the first information related to the first image does not match with the second information related to the second image, configure the capsule device to capture third images at the target rate.

17. The capsule device of claim 16, wherein the capsule device further comprising an archival memory to store the third images and the archival memory is enclosed in the capsule housing.

18. The capsule device of claim 16, wherein the processing unit is inside the capsule housing.

19. The capsule device of claim 16, wherein the capsule device further comprising a wireless transmitter inside the capsule housing to transmit the first images to a wireless receiver external to the capsule device.

20. The capsule device of claim 19, wherein the processing unit is external to the capsule device.

21. The capsule device of claim 16, wherein the coating corresponds to an enteric coating.

22. The capsule device of claim 21, wherein a material for the enteric coating is selected from an enteric group consisting of carboxymethylcellulose cellulose (CMC), acid substituted cellulose, diacid substituted cellulose such as phthalate and succinate but not limited to those, triacid substituted cellulose such as trimellitic acid and citric acid (CAT), acid substituted poly(vinyl alcohol or acetate) (PVA/PVAP), acid-, diacid-, or triacid substituted hydroxypropyl methylcellulose such as phtallic-, succinic-, trimetellitic-, and citric- but not limited to those, various substituted methacrylic- and acrylic acid copolymers, fatty acids, waxes, shellac (esters of aleuritic acid (pH 7.0), plastics, and plant fiber.

23. The capsule device of claim 22, wherein a material for the enteric coating is more specifically selected from an enteric group consisting of carboxymethylcellulose (CMC) (solubility>

pH 5.0), cellulose acetate phthalate (CAP) (solubility>

pH 6.2),cellulose acetate trimellitate (CAT) (pH 5.0), poly(vinyl acetate phthalate) (PVAP) (>

pH 5.2), hydroxypropyl methylcellulose phthalate (HPMCP) (>

pH 4.5-5.5), cellulose acetate succinate (solubility pH>

5.5-7.0), methacrylic acid copolymer type, poly(methacrylic acid-co-methyl methacrylate (pH 5.5-7.0), poly(methyl acrylate-co-methacrylic acid-co-methyl methacrylate (pH 5.5-7.0), poly(methyl acrylate-co-methacrylic acid-co-ethyl methacrylate), poly(ethyl acrylate-co-methacrylic acid-co-methyl methacrylate) poly(methacrylic acid-co-ethyl methacrylate) fatty acids, waxes, shellac (esters of aleuritic acid (pH 7.0), plastics, and plant fiber.

24. The capsule device of claim 16, wherein the coating corresponds to an enzymatic coating.

26. The capsule device of claim 16, wherein the coating has a double layer structure with inner coating being ionic and outer layer being an enteric coating, wherein water diffuses through the enteric coating into the ionic coating, which absorbs the water and once a sufficient amount of water has been absorbed by the inner layer the outer coating cracks which allow the whole coating matrix to come off.

27. The capsule device of claim 26, wherein a material for the coating is selected from a group consisting of hydrophobic surfactant, water-soluble polymer, and hydroxypropyl methylcellulose (HPMC).

25. The capsule device of claim 244, wherein a material for the enzymatic coating is selected from an enzymatic group consisting of Encode, azo crosslinked polymers such as methacrylic acid and/or acrylic acid copolymers, carboxmethylcellulose, hydroxypropylmethylcellulose, methacryloxy azobenzene HEMA, diisocyanate crosslinked dextran.