HEART VALVE PROSTHESIS FOR CONTROLLED THROMBUS DEVELOPMENT

• US 20170252155A1
• Filed: 03/01/2017
• Published: 09/07/2017
• Est. Priority Date: 03/03/2016
• Status: Active Grant

• Current Assignee: Biotronik AG (Biotronik SE & Company KG)
• Original Assignee: Biotronik AG (Biotronik SE & Company KG)
• Inventors: Quint, Bodo
• Granted Patent: US 10,709,554 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/246 Devices for obstructing a leak through a native valve in a closed condition
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0069 Sealing means
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 2430/20 for reconstruction of the heart, e.g. heart valves
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

The invention relates to a heart valve prosthesis including a heart valve a main body for supporting the heart valve. The heart valve includes a terminating material selected from material and configured to at least partially close a paravalvular leak by controlled thrombus development.

Claims

1. A heart valve prosthesis, comprising a heart valve and a main body for supporting the heart valve, wherein the heart valve is secured to the main body and a terminating material on an outer side of the main body formed of material and configured to induce a thrombus.

2. The heart valve prosthesis according to claim 1, wherein the terminating material comprises liquid permeable material.

3. The heart valve prosthesis according to claim 1, wherein the terminating material comprises at least one of a polymer, a biological polymer, an artificial polymer, a cationic polymer, a polycation, or chitosan.

4. The heart valve prosthesis according to claim 1, wherein the terminating material consists of a polymer, a biological polymer, an artificial polymer, a cationic polymer, a polycation, or chitosan

5. The heart valve prosthesis according to claim 1 wherein the terminating material is arranged in a blood-permeable bag, which is arranged on the outer side of the main body and is secured to the main body.

6. The heart valve prosthesis according to claim 5, wherein the bag comprises at least one of polyethylene, polyethylene terephthalate, polyethylene succinate, polybutylene succinate, polyester, polylactide, and polycaprolactone.

7. The heart valve prosthesis according to claim 5, wherein the bag consists of one of polyethylene, polyethylene terephthalate, polyethylene succinate, polybutylene succinate, polyester, polylactide, and polycaprolactone.

8. The heart valve prosthesis according to claim 1, wherein the terminating material comprises a plurality of fibres.

9. The heart valve prosthesis according to claim 8, wherein the fibres are formed form multi-filaments, each comprising a plurality of interconnected fibres.

10. The heart valve prosthesis according to claim 8, wherein the fibres are secured to the main body in an integrally bonded, force-fitting and/or form-fitting manner.

11. The heart valve prosthesis according to claim 8, wherein individual fibres are configured and of material to deform upon contact with water from an elongate first state into a second state, wherein the fibres in the second state have a multiplicity of curvatures.

12. The heart valve prosthesis according to claim 8, wherein the fibres comprise a polymer mixture, wherein the polymer mixture comprises chitosan and a water-insoluble polymer.

13. The heart valve prosthesis according to claim 12, wherein the water-insoluble polymer comprises P(VP-co-VAc).

14. The heart valve prosthesis according to claim 8, wherein individual fibres are are coated with a soluble polymer.

15. The heart valve prosthesis according to claim 14, wherein he soluble polymer is selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, hyaluronic acid, and polysugars,

16. The heart valve prosthesis according to claim 14, wherein the polysugars are selected from pullulan or dextrans.

17. The heart valve prosthesis according to claim 8, wherein the fibres comprise polycation fibres and a surrounding shell formed of rigid supporting fibres.

18. The heart valve prosthesis according to claim 1, wherein the main body is expandable or self-expandable.

19. The heart valve prosthesis according to claim 1, wherein the heart valve prosthesis is configured to be implanted by catheter.