Combination Kidney and Liver Dialysis System and Method
First Claim
1. A system for treating multiple organ dysfunction syndrome through a complex multicomponent hemodialysis device, the system comprising:
- at least one pump, the at least one pump configured to enable pumping of blood;
at least one replacement fluid mixer, the at least one replacement fluid mixer configured to enable adding at least one replacement fluid to the blood;
a membrane plasma separator, the membrane plasma separator configured to enable separation of the blood into a cellular portion and a plasma portion;
a high flux dialyzer, the high flux dialyzer comprising different dialysates having a low concentration of minerals;
a plurality of hemodiafiltration membranes;
a hemoperfusion membrane, the hemoperfusion membrane defined by high molecular weight cut off;
an albumin dialyzer, the albumin dialyzer comprising a high molecular weight cut off membrane and an albumin dialysate, the albumin dialysate comprising at least one of the following;
a 5%-25% albumin solution, an activated charcoal, a polystyrene sulfonate, and resin;
a lipid dialysate, the lipid dialysate comprising about 10 to 30 percent lipids or oils; and
an extracorporeal membrane oxygenation membrane, the extracorporeal membrane oxygenation membrane configured to enable at least partial oxygenation of the cellular portion of the blood.
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Accused Products
Abstract
A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.
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Citations
25 Claims
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1. A system for treating multiple organ dysfunction syndrome through a complex multicomponent hemodialysis device, the system comprising:
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at least one pump, the at least one pump configured to enable pumping of blood; at least one replacement fluid mixer, the at least one replacement fluid mixer configured to enable adding at least one replacement fluid to the blood; a membrane plasma separator, the membrane plasma separator configured to enable separation of the blood into a cellular portion and a plasma portion; a high flux dialyzer, the high flux dialyzer comprising different dialysates having a low concentration of minerals; a plurality of hemodiafiltration membranes; a hemoperfusion membrane, the hemoperfusion membrane defined by high molecular weight cut off; an albumin dialyzer, the albumin dialyzer comprising a high molecular weight cut off membrane and an albumin dialysate, the albumin dialysate comprising at least one of the following;
a 5%-25% albumin solution, an activated charcoal, a polystyrene sulfonate, and resin;a lipid dialysate, the lipid dialysate comprising about 10 to 30 percent lipids or oils; and an extracorporeal membrane oxygenation membrane, the extracorporeal membrane oxygenation membrane configured to enable at least partial oxygenation of the cellular portion of the blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for treating multiple organ dysfunction syndrome through dialysis of blood, the method comprising:
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pumping blood from a body; adding a first replacement fluid to the blood; passing the blood through a high flux dialyzer, the high flux dialyzer comprising a standard dialysate or a low calcium bath; separating the blood into a plasma portion and a cellular portion; returning the cellular portion of the blood to the body upon separation of the blood; adding a second replacement fluid to the plasma portion of the blood; passing the plasma portion through a plurality of hemodiafiltration membranes; passing the plasma portion through a hemoperfusion membrane; adding a third replacement fluid to the plasma portion of the blood; dialyzing the plasma portion of the blood through an albumin dialyzer, the albumin dialyzer comprising a high molecular weight cut off membrane and an albumin dialysate, the albumin dialysate comprising at least one of the following;
albumin, activated charcoal, a polystyrene sulfonate, and resin;dialyzing the plasma portion against a lipid dialysate, the lipid dialysate comprising about 10 to 30 percent lipids or oils by weight or volume; and passing the cellular portion through an extracorporeal membrane oxygenation membrane, the extracorporeal membrane oxygenation membrane configured to oxygenate the cellular portion. - View Dependent Claims (18, 19)
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20. A system for treating multiple organ dysfunction syndrome through a multi-component hemodialysis device, the system comprising:
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at least one replacement fluid mixer, the at least one replacement fluid mixer configured to enable adding several replacement fluids to the blood and its portions in prespecified positions; a membrane plasma separator, the membrane plasma separator having a plasmapheresis membrane, the membrane plasma separator configured to enable separation of the blood into a cellular portion and a plasma portion; a high flux dialyzer, the high flux dialyzer comprising a standard dialysates and a dialysate having a low concentration of calcium; at least one hemofilter, the at least one hemofilter comprising hollow fibers defined by a small diameter; a hemodialysis filter, the hemodialysis filter disposed in series with the at least one hemofilter; a hemoperfusion membrane, the hemoperfusion membrane comprising activated microporous charcoal and a resin; an albumin dialyzer, the albumin dialyzer comprising a high molecular weight cut off membrane and an albumin dialysate, the albumin dialysate comprising at least one of the following;
a 5%-25% albumin solution alone or in solution with activated charcoal, polystyrene sulfonate, and second resin; and - View Dependent Claims (21, 22, 23, 24, 25)
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Specification