Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist and/or Agonist of an Immune Checkpoint Inhibitor
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Abstract
The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination with antagonists or agonists of immune checkpoint inhibitors.
15 Citations
169 Claims
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1-132. -132. (canceled)
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133. A method for treating a human cancer patient comprising:
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(a) administering to the patient a recombinant poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA); and (b) administering to the patient a PD-1 antagonist and a CTLA-4 antagonist. - View Dependent Claims (134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147)
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148. A method for treating cancer in a human cancer patient, the method comprising administering to the patient a combination of:
- (a) a therapeutically effective amount of a recombinant poxvirus, the poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA); and
(b) a therapeutically effective amount of at least one immune checkpoint antagonist or agonist, wherein the therapeutically effective amount of the at least one immune checkpoint antagonist or agonist is such that the therapeutic effect of the combination is increased as compared to an administration of either (1) the poxvirus vector encoding a polypeptide comprising at least one TAA alone or (2) the at least one immune checkpoint antagonist or agonist alone or in combination with other immune checkpoint antagonists or agonists. - View Dependent Claims (149, 150, 151, 152, 153, 154, 155, 156, 157, 158)
- (a) a therapeutically effective amount of a recombinant poxvirus, the poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA); and
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159. A pharmaceutical combination for treating cancer in a human patient, the combination comprising:
- (a) a recombinant poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA);
(b) a PD-1 antagonist; and
(c) a CTLA-4 antagonist. - View Dependent Claims (160, 161, 162, 163, 164, 165, 166)
- (a) a recombinant poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA);
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167. A pharmaceutical combination for treating cancer in a human patient, comprising:
- (a) a therapeutically effective amount of a recombinant poxvirus, the poxvirus encoding a polypeptide comprising at least one tumor associated antigen (TAA); and
(b) a therapeutically effective amount of at least one immune checkpoint antagonist or agonist, wherein the therapeutically effective amount of the at least one immune checkpoint antagonist or agonist is such that the therapeutic effect of the combination is increased as compared to an administration of either (1) the poxvirus vector encoding a polypeptide comprising at least one TAA alone or (2) the at least one immune checkpoint antagonist or agonist alone or in combination with other immune checkpoint antagonists or agonists. - View Dependent Claims (168, 169)
- (a) a therapeutically effective amount of a recombinant poxvirus, the poxvirus encoding a polypeptide comprising at least one tumor associated antigen (TAA); and
Specification