PREDICTION, VISUALIZATION, AND CONTROL OF DRUG DELIVERY BY MULTIPLE INFUSION PUMPS

• US 20170266377A1
• Filed: 05/14/2015
• Published: 09/21/2017
• Est. Priority Date: 05/15/2014
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.), Steward St. Elizabeth'S Medical Center Of Boston, Inc. (Steward Health Care Holdings LLC)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Peterfreund, Robert A., Parker, Michael, Lovich, Mark A.
• Granted Patent: US 10,758,672 B2
• Time in Patent Office: Days
• CPC Class Codes: A61M 2005/14292 Computer-based infusion planning or simulation of spatio-temporal infusate distribution
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/6054 Magnetic identification systems
• CPC Class Codes: A61M 5/14232 Roller pumps
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G06F 30/00 Computer-aided design [CAD]
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The subject technology is embodied in a method for predicting a delivery rate of a plurality of drugs dispensed by multiple infusion pumps at a delivery point. The method includes receiving one or more operating parameters related to multiple drug pumps and a carrier fluid pump, wherein each of the drug pumps dispenses a drug, and the carrier fluid pump dispenses a carrier fluid. The method also includes determining a delivery rate of a first drug at the delivery point. This can be done by predicting time variation of a concentration of the first drug at the delivery point based on a mathematical model of a mixed flow through a fluid path that terminates at the delivery point. The mixed flow includes the drugs and the carrier fluid. The model includes the operating parameters and a plurality of flow-parameters related to the mathematical model of the mixed flow.

Claims

1-32. -32. (canceled)

33. A method for predicting a delivery rate of a plurality of drugs at a delivery point, the method comprising:

receiving, at a processing device, one or more operating parameters related to multiple drug pumps each of which dispenses a drug, and a carrier fluid pump that dispenses a carrier fluid; and

determining, by the processing device, a delivery rate of a first drug at the delivery point by predicting time variation of a concentration of the first drug at the delivery point based at least on a mathematical model of a mixed flow through a fluid path that terminates at the delivery point,

wherein the mixed flow comprises the first drug, at least a second drug, and the carrier fluid, and wherein the model includes the one or more operating parameters and a plurality of flow-parameters related to the mathematical model of the mixed flow.

34. A method for controlling a drug delivery profile, the method comprising:

receiving, at a processing device, information on drug flow rates related to multiple drug pumps each of which dispenses a drug and information on a carrier fluid flow rate related to a carrier fluid pump that dispenses a carrier fluid; and

controlling, by a control module, the delivery profile of at least two drugs at a delivery point by adjusting the drug flow rates of the at least two drugs and the carrier fluid flow rate, such that the flow rate of a second drug is constrained to vary within a predetermined range when the flow rate of at least a first drug and the flow rate of the carrier fluid is adjusted.