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Cytotoxicity-Inducing Therapeutic Agent

  • US 20170267783A1
  • Filed: 03/23/2017
  • Published: 09/21/2017
  • Est. Priority Date: 09/26/2014
  • Status: Active Grant
First Claim
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1. A multispecific antigen-binding molecule that comprises:

  • (1) a domain comprising an antibody variable region having glypican 3-binding activity,(2) a domain comprising an antibody variable region having T-cell receptor complex-binding activity, and(3) a domain comprising an Fc region with reduced binding activity towards an Fcγ

    receptor,wherein the antibody variable region of (1) and the antibody variable region of (2) have a common L-chain amino acid sequence; and

    wherein the multispecific antigen-binding molecule has a cytotoxic activity equivalent to or greater than the cytotoxic activity of a bispecific antibody having a glypican 3-binding domain comprising SEQ ID NOs;

    47 and 48, and a T-cell receptor complex-binding domain comprising SEQ ID NOs;

    49 and 50.

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