DRUG DELIVERY KIT, AND APPARATUS AND METHOD FOR PREPARING DRUG DELIVERY SYSTEM

• US 20170274137A1
• Filed: 04/19/2016
• Published: 09/28/2017
• Est. Priority Date: 04/20/2015
• Status: Active Grant

• Current Assignee: Tgel Bio Co., Ltd.
• Original Assignee: Tgel Bio Co., Ltd.
• Inventors: HWANG, Changsoon, KIM, Sun Jong, CHO, Han Weon, HAM, Sunhee, CHUNG, Hyesook
• Granted Patent: US 10,391,233 B2
• Time in Patent Office: Days
• CPC Class Codes: A61J 1/1412 Containers with closing means, e.g. caps
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 5/002 Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics needle protection, e.g. caps, A61M5/3202; for sharps A61B50/3001
• CPC Class Codes: A61M 5/178 Syringes
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001

Abstract

Disclosed is a drug delivery kit, including an apparatus for preparing a drug delivery system, which includes therein a drug carrier in a gel phase or a solid phase under the airtight condition, and has therein a mixing space configured such that a drug for forming a drug delivery system with the drug carrier is injected from the outside and is mixed with the drug carrier, and a syringe for injecting the drug into the apparatus for preparing a drug delivery system. Also, an apparatus for preparing a drug delivery system, which can be applied to the drug delivery kit, and a method of preparing a drug delivery system using the apparatus are provided. The drug delivery system can be easily prepared on site, whereby the drug can be delivered in vivo.

Claims

1. A drug delivery kit, comprising:

an apparatus for preparing a drug delivery system, which includes therein a drug carrier in a gel phase or a solid phase under an airtight condition, and has therein a mixing space configured such that a drug for forming a drug delivery system with the drug carrier is injected from outside and is mixed with the drug carrier; and

a syringe for injecting the drug into the apparatus for preparing a drug delivery system.

2. The drug delivery kit of claim 1, wherein the drug is dissolved or suspended in a solvent, or at least a portion of the drug is contained in a microsphere.

3. The drug delivery kit of claim 1, wherein the drug carrier comprises a gel-forming polymer.

4. The drug delivery kit of claim 3, wherein the drug carrier further comprises a gel-forming assistant for aiding formation of a polymer gel.

5. The drug delivery kit of claim 1, wherein the drug delivery system is a liquid at room temperature and is a gel or solid at body temperature.

6. The drug delivery kit of claim 1, wherein the drug carrier in a solid phase is a mixture comprising poly(ethylene oxide-propylene oxide-ethylene oxide) and sodium hyaluronate, which area solid.

7. The drug delivery kit of claim 1, wherein the apparatus includes a drug injection part at one side thereof so that a syringe needle is placed in or withdrawn from the apparatus and so that an inside of the apparatus is kept airtight when the syringe needle is placed in or withdrawn from the apparatus.

8. The drug delivery kit of claim 1, wherein the apparatus further includes a stirring element therein.

9. The drug delivery kit of claim 8, wherein the stirring element includes at least one selected from among a stirring magnet, a stirring rod, a stirring plate, and a stirring ball.

10. The drug delivery kit of claim 9, wherein the stirring rod is provided in rod form, and includes a stirring magnet therein.

11. The drug delivery kit of claim 9, wherein at least one side of the stirring rod includes a projection part.

12. The drug delivery kit of claim 1, further comprising a temperature control chamber.

13. The drug delivery kit of claim 12, wherein the temperature control chamber comprises a casing, an apparatus fixer for fixing the apparatus in the casing, and a temperature control medium holding recess for receiving a temperature control medium in the casing.

14. The drug delivery kit of claim 13, wherein the apparatus fixer comprises a first subunit that directly contacts the apparatus and a second subunit for fixedly connecting the first subunit to the casing.

15. The drug delivery kit of claim 14, wherein one side of the first subunit includes a fixing end formed to protrude in a direction toward the apparatus so as to fix the apparatus, and a remaining side of the first subunit is removably fixed to one side of the second subunit.

16. The drug delivery kit of claim 1, further comprising a stirrer for mixing the drug carrier and the drug, which are maintained in the apparatus for preparing a drug delivery system.

17. The drug delivery kit of claim 16, wherein the stirrer comprises at least one selected from among a direct stirrer for directly mixing the drug carrier and the drug, an indirect stirrer for indirectly mixing the drug carrier and the drug through motion of the apparatus, and a direct-indirect stirrer for indirectly mixing the drug carrier and the drug while directly mixing the drug carrier and the drug.

18. The drug delivery kit of claim 1, wherein the drug carrier in a solid phase is a lyophilized material.

19. An apparatus for preparing a drug delivery system, which includes therein a drug carrier in a gel phase or a solid phase under an airtight condition, and has therein a mixing space configured such that a drug for forming a drug delivery system with the drug carrier is injected from outside and is mixed with the drug carrier.

20. The apparatus of claim 19, wherein the drug carrier in a solid phase is a lyophilized material.

21. The apparatus of claim 19, wherein the apparatus is placed into a temperature control chamber.

22. A method of preparing a drug delivery system, comprising:

(A) providing an apparatus for preparing a drug delivery system, which includes therein a drug carrier in a gel phase or a solid phase under an airtight condition, and has therein a mixing space configured such that a drug for forming a drug delivery system with the drug carrier is injected from outside and is mixed with the drug carrier;

(B) injecting the drug into the apparatus for preparing a drug delivery system; and

(C) mixing the drug and the drug carrier in the mixing space, thus forming the drug delivery system.

23. The method of claim 22, wherein the injecting is performed using a syringe.

24. The method of claim 22, wherein the mixing is performed under a condition that the apparatus, into which the drug and the drug carrier are injected, is placed into a temperature control chamber.