ENDOLUMINAL PROSTHETIC DEVICES HAVING FLUID-ABSORBABLE COMPOSITIONS FOR REPAIR OF A VASCULAR TISSUE DEFECT

• US 20170281331A1
• Filed: 03/28/2017
• Published: 10/05/2017
• Est. Priority Date: 03/31/2016
• Status: Abandoned Application

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Perkins, Keith, Petruska, Matthew, Robaina, Samuel, Galligan, Darren, Radhakrishnan, Rajesh
• Application Number:
  US15/471,078
• Publication Number:
  US 20170281331A1
• Time in Patent Office: Days
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/885 comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/077 having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
• CPC Class Codes: A61F 2210/0014 using shape memory or superelastic materials, e.g. nitinol
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas

Abstract

Endoluminal prosthetic devices having fluid-absorbable compositions for repair of vascular tissue defects, such as an aneurysm or dissection, are disclosed herein. A prosthesis for repairing an opening or cavity within a target vessel region configured in accordance herewith includes a tubular body sized to substantially cover the opening or cavity, and having channels formed in a wall thereof. The channels can include a fluid-absorbable composition deposited therein and which is configured to absorb fluid (e.g., blood) and swell within the channels, thereby providing radial expansion of the tubular body in situ.

Claims

1. A prosthesis having a compressed configuration for delivery within a vasculature and a radially-expanded configuration for deployment within a target blood vessel in a patient, the prosthesis comprising:

a tubular body having

a first end and a second end, the first end having an anchoring structure to engage an inner wall of the target blood vessel in the radially-expanded configuration; and

an elongated mid-portion between the first and second ends and including a channel formed in a wall thereof, wherein the channel is at least partially oriented circumferentially about the tubular body; and

a fluid-absorbable composition deposited within the channel, the fluid-absorbable composition having a first volume when the prosthesis is in the compressed configuration and configured to swell to a second volume within the channel upon deployment of the prosthesis within the target blood vessel to thereby transition at least the elongated mid-portion into the radially-expanded configuration.

2. The prosthesis of claim 1, wherein the channel is a plurality of channels formed in the wall of the elongated mid-portion, and wherein the second volume increases hydrostatic pressure within the plurality of channels to produce a structural scaffold about the elongated mid-portion.

3. The prosthesis of claim 2, wherein the tubular body defines a lumen through which blood may flow, and wherein the structural scaffold provides buckling resistance at the elongated mid-portion.

4. The prosthesis of claim 1, wherein the tubular body comprises a flexible sheet having opposing inner and outer layers that form the wall of the tubular body and between which the channel is defined.

5. The prosthesis of claim 4, wherein the inner and outer layers are selected from one or more of polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), ultra-high-molecular-weight polyethylene (UHMWPE), polyurethane and polyester.

6. The prosthesis of claim 5, wherein the inner and outer layers comprise different materials.

7. The prosthesis of claim 1, wherein the fluid-absorbable composition is a hydrogel or hydrophilic foam.

8. The prosthesis of claim 1, wherein the channel is formed in one of a circumferential ring, a diamond pattern, a chevron pattern, a crisscross pattern, a spiral pattern and a sinusoidal pattern about the elongated mid-portion.

9. The prosthesis of claim 1, further comprising:

one or more wires disposed within the channel, wherein the fluid-absorbable composition at least partially surrounds the wire.

10. The prosthesis of claim 1, wherein the prosthesis is configured to substantially cover an enlarged area or cavity in the target blood vessel when the prosthesis is in the radially-expanded configuration.

11. The prosthesis of claim 10, wherein the enlarged area or cavity is an abdominal aortic aneurism or a thoracic aortic aneurysm, and wherein the prosthesis is implanted in the aorta in a manner to occlude the aneurism.

21. The prosthesis of claim 1, further comprising:

a branch stent-graft for directing fluid flow to a branch vessel from the target blood vessel.

22. The prosthesis of claim 1, further comprising:

a bifurcated portion having first and second tubular legs coupled to the second end of the tubular body, wherein;

the first and second tubular legs define lumens that are in fluid communication with a lumen defined by the tubular body, and

the tubular body is configured for placement within the abdominal aorta and the first and second tubular legs are configured for left and right iliac artery placement.

23. The prosthesis of claim 1, wherein the anchoring structure includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts, wherein a first proximal-most set of crowns extend beyond a first edge of the tubular body and a second opposing set of crowns is coupled to the first end of the tubular body.

12. An expandable prosthetic device for implantation at a target blood vessel region to treat a target tissue defect in a patient, the device comprising:

a tubular body formed of graft material, the tubular body having a wall between first and second ends and a lumen defined by the wall;

a self-expanding anchor stent coupled to the first end for anchoring within the target blood vessel region when the device is implanted; and

a plurality of expandable flanges arranged on an outer surface of the wall of the tubular body in a geometric pattern, wherein each expandable flange includes an encapsulation material coupled to the outer surface of the wall for forming a channel therebetween, and

a fluid-absorbable composition contained within the channel, wherein the fluid-absorbable composition at least partially swells upon exposure to bodily fluids in situ,

wherein at least partial swelling of the fluid-absorbable composition within the channel aids in radial expansion of the tubular body.

13. The device of claim 12, wherein the encapsulation material is coupled to the outer surface of the wall to define tubes configured to limit the swelling of the fluid-absorbable composition therein.

14. The device of claim 13, wherein the flanges provide turgid support structures when the fluid-absorbable composition swells within the tubes, and wherein the turgid support structures are configured to at least provide an outward radial strength to the wall of the tubular body.

15. The device of claim 12, wherein the lumen provides a passage through which blood may flow when the at least partial swelling of the fluid-absorbable composition provides radial expansion of the tubular body.

16. The device of claim 12, wherein the geometric pattern on the outer surface of the wall of the tubular body includes at least one of longitudinally-spaced apart circumferential rings, a diamond pattern, a chevron pattern, a crisscross pattern, a spiral pattern and a sinusoidal pattern.

17. The device of claim 16, wherein a central axis through the circumferential rings is substantially parallel to a longitudinal axis of the tubular body.

18. The device of claim 12, wherein one or more flanges provide a radial force against the inner wall of the target blood vessel region.

19. The device of claim 12, wherein:

the graft material is one of polyester and polyethylene terephthalate;

the encapsulation material is one of ePTFE, polyurethane and polyester; and

the fluid-absorbable composition is a hydrogel.

20. The device of claim 12, wherein the target tissue defect is an abdominal aortic aneurism or a thoracic aortic aneurism, and wherein the device is implanted in the aorta in a manner to occlude the aneurism.