FUSION PROTEIN, NANOPARTICLE COMPOSED OF A PLURALITY OF MONOMERS OF SAID FUSION PROTEIN, AND USES THEREOF
First Claim
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1. A fusion protein comprising at least three domains, wherein:
- (a) a first domain comprises the amino acid sequence of the heavy chain of native human ferritin or a variant thereof having at least 90% identity with the amino acid sequence of the heavy chain of native human ferritin;
(b) a second domain comprises the amino acid sequence of a matrix metalloproteinase (MMP) cleavage site; and
(c) a third N-terminal domain consists of the amino acid sequence of a polypeptide of at least 20 amino acid residues and which essentially consists of proline, serine and alanine (PAS).
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Abstract
A fusion protein based on the heavy chain of human ferritin is described, which includes at the N terminus of the protein at least one metalloproteinase cleavage sequence and a PAS polypeptide that acts as a masking polymer that increases the protein-drug stability, as well as a nanoparticle composed of multiple monomers of said fusion protein, a nucleic acid encoding for said fusion protein, and diagnostic and therapeutic applications thereof.
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Citations
17 Claims
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1. A fusion protein comprising at least three domains, wherein:
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(a) a first domain comprises the amino acid sequence of the heavy chain of native human ferritin or a variant thereof having at least 90% identity with the amino acid sequence of the heavy chain of native human ferritin; (b) a second domain comprises the amino acid sequence of a matrix metalloproteinase (MMP) cleavage site; and (c) a third N-terminal domain consists of the amino acid sequence of a polypeptide of at least 20 amino acid residues and which essentially consists of proline, serine and alanine (PAS). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification