Tissue Engineering Methods and Compositions
First Claim
1. A composition for use in the treatment of osteoarthritis in a subject, the composition comprising:
- an adipose-derived stem cell and an effective amount of a biologically active agent; and
a pharmaceutically acceptable carrier or excipient, wherein;
the biologically activate agent is a BMP-6 polypeptide or a functional fragment thereof,the adipose-derived stem cell is exposed to the effective amount of said biologically active agent, andthe effective amount of the biologically active agent is sufficient to induce the adipose-derived stem cell to differentiate into a cell capable of treating the osteoarthritis in the subject upon administration of the composition to the subject.
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Abstract
A composition for use in the treatment of osteoarthritis in a subject includes an adipose-derived stem cell and an effective amount of a biologically active agent. The composition also includes a pharmaceutically acceptable carrier or excipient. The biologically activate agent is a BMP-6 polypeptide or a functional fragment thereof. The treatment includes exposing the ADS cell to an effective amount of said biologically active agent. The effective amount of the biologically active agent is sufficient to induce the adipose-derived stem cell to differentiate into a cell capable of treating the osteoarthritis in the subject upon administration of the composition to the subject.
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Citations
19 Claims
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1. A composition for use in the treatment of osteoarthritis in a subject, the composition comprising:
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an adipose-derived stem cell and an effective amount of a biologically active agent; and a pharmaceutically acceptable carrier or excipient, wherein; the biologically activate agent is a BMP-6 polypeptide or a functional fragment thereof, the adipose-derived stem cell is exposed to the effective amount of said biologically active agent, and the effective amount of the biologically active agent is sufficient to induce the adipose-derived stem cell to differentiate into a cell capable of treating the osteoarthritis in the subject upon administration of the composition to the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification